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PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α with IC 50 =156 nM/186nM that inhibits the kinase activity of TAK1 by binding to its active site.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $90 | In Stock | |
5 mg | $222 | In Stock | |
10 mg | $355 | In Stock | |
25 mg | $712 | In Stock | |
1 mL x 10 mM (in DMSO) | $245 | In Stock |
Description | PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α with IC 50 =156 nM/186nM that inhibits the kinase activity of TAK1 by binding to its active site. |
Targets&IC50 | p38α:186 nM, TAK1:156 nM |
In vitro | PF-05381941 inhibits TNF-α release from LPS-stimulated human peripheral mononuclear (PMN) cells with an IC50 value of 8 nM. [1] |
Alias | PF05381941 |
Molecular Weight | 466.53 |
Formula | C27H26N6O2 |
Cas No. | 1474022-02-0 |
Smiles | N#CC1=CC=CC(=C1)N2N=C(C=C2NC(=O)NC3=CC=C(OC=4C=CN=CC4)C(=C3)C)C(C)(C)C |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (171.48 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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