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PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α with IC 50 =156 nM/186nM that inhibits the kinase activity of TAK1 by binding to its active site.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $877 | In Stock | |
50 mg | $1,140 | In Stock | |
100 mg | $1,820 | 6-8 weeks |
Description | PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α with IC 50 =156 nM/186nM that inhibits the kinase activity of TAK1 by binding to its active site. |
Targets&IC50 | TAK1:156 nM, p38α:186 nM |
In vitro | PF-05381941 inhibits TNF-α release from LPS-stimulated human peripheral mononuclear (PMN) cells with an IC50 value of 8 nM. [1] |
Alias | PF05381941 |
Molecular Weight | 466.53 |
Formula | C27H26N6O2 |
Cas No. | 1474022-02-0 |
Smiles | Cc1cc(NC(=O)Nc2cc(nn2-c2cccc(c2)C#N)C(C)(C)C)ccc1Oc1ccncc1 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (171.48 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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