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PF-05381941

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Catalog No. T36017Cas No. 1474022-02-0
Alias PF05381941

PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α with IC 50 =156 nM/186nM that inhibits the kinase activity of TAK1 by binding to its active site.

PF-05381941

PF-05381941

😃Good
Catalog No. T36017Alias PF05381941Cas No. 1474022-02-0
PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α with IC 50 =156 nM/186nM that inhibits the kinase activity of TAK1 by binding to its active site.
Pack SizePriceAvailabilityQuantity
25 mg$877 In Stock
50 mg$1,140 In Stock
100 mg$1,820 6-8 weeks
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Product Introduction

Bioactivity
Description
PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α with IC 50 =156 nM/186nM that inhibits the kinase activity of TAK1 by binding to its active site.
Targets&IC50
TAK1:156 nM, p38α:186 nM
In vitro
PF-05381941 inhibits TNF-α release from LPS-stimulated human peripheral mononuclear (PMN) cells with an IC50 value of 8 nM. [1]
AliasPF05381941
Chemical Properties
Molecular Weight466.53
FormulaC27H26N6O2
Cas No.1474022-02-0
SmilesCc1cc(NC(=O)Nc2cc(nn2-c2cccc(c2)C#N)C(C)(C)C)ccc1Oc1ccncc1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (171.48 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1435 mL10.7174 mL21.4348 mL107.1742 mL
5 mM0.4287 mL2.1435 mL4.2870 mL21.4348 mL
10 mM0.2143 mL1.0717 mL2.1435 mL10.7174 mL
20 mM0.1072 mL0.5359 mL1.0717 mL5.3587 mL
50 mM0.0429 mL0.2143 mL0.4287 mL2.1435 mL
100 mM0.0214 mL0.1072 mL0.2143 mL1.0717 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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