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SHP389

Name: SHP389
Brand: TargetMol
SKU: T39726
Price: 165 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39726Cas No. 2235394-90-6

Alias SHP 389

SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.

SHP389

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Purity: 98.24%

Catalog No. T39726Alias SHP 389Cas No. 2235394-90-6

SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$165	In Stock	In Stock
5 mg	$413	In Stock	In Stock
10 mg	$689	-	In Stock
25 mg	$1,480	-	In Stock
50 mg	$2,280	-	In Stock
1 mL x 10 mM (in DMSO)	$453	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.24%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.
Targets&IC50	SHP2:36 nM
In vitro	SHP389 is an allosteric inhibitor of SHP2 with IC50 of 36 nM for SHP2. SHP389 showed high clearance in rat liver microsomes in vitro (Cl = 26.1 μL/min/mg, T1/2 = 53.2 min), large distribution volume (3.9 L/kg), terminal half-life of 2.7 h, and oral bioavailability of 2%. [2]
In vivo	SHP389 modulates MAPK signaling in vivo[1].
Synonyms	SHP 389

Chemical Properties

Molecular Weight	484.98
Formula	C₂₃H₂₉ClN₈O₂
Cas No.	2235394-90-6
Smiles	N[C@H]1C2(CCN(CC2)C3=NC=4C(C(=O)N3C)=C(NN4)C=5C(Cl)=C(NC6CC6)N=CC5)CO[C@H]1C
Relative Density.	1.67 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (164.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0619 mL	10.3097 mL	20.6194 mL	103.0970 mL
5 mM	0.4124 mL	2.0619 mL	4.1239 mL	20.6194 mL
10 mM	0.2062 mL	1.0310 mL	2.0619 mL	10.3097 mL
20 mM	0.1031 mL	0.5155 mL	1.0310 mL	5.1549 mL
50 mM	0.0412 mL	0.2062 mL	0.4124 mL	2.0619 mL
100 mM	0.0206 mL	0.1031 mL	0.2062 mL	1.0310 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc