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ZY-444

🥰Excellent
Catalog No. T62620Cas No. 1802650-31-2

ZY-444 is a small molecule inhibiting the progression of breast cancer by targeting pyruvate carboxylase.

ZY-444

ZY-444

🥰Excellent
Purity: 99.14%
Catalog No. T62620Cas No. 1802650-31-2
ZY-444 is a small molecule inhibiting the progression of breast cancer by targeting pyruvate carboxylase.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$88In StockIn Stock
5 mg$213In StockIn Stock
10 mg$313In StockIn Stock
25 mg$662In StockIn Stock
50 mg$996In StockIn Stock
100 mg$1,820-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.14%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
ZY-444 is a small molecule inhibiting the progression of breast cancer by targeting pyruvate carboxylase.
Chemical Properties
Molecular Weight444.59
FormulaC26H28N4OS
Cas No.1802650-31-2
SmilesN=1C=CC(=NC1NCC(C)C)NCC=2SC(=CC2)C=3C=CC(OCC=4C=CC=CC4)=CC3
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (179.94 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 3.3 mg/mL (7.42 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2493 mL11.2463 mL22.4926 mL112.4632 mL
5 mM0.4499 mL2.2493 mL4.4985 mL22.4926 mL
10 mM0.2249 mL1.1246 mL2.2493 mL11.2463 mL
20 mM0.1125 mL0.5623 mL1.1246 mL5.6232 mL
50 mM0.0450 mL0.2249 mL0.4499 mL2.2493 mL
100 mM0.0225 mL0.1125 mL0.2249 mL1.1246 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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