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CST626

🥰Excellent
Catalog No. T78947Cas No. 3033993-13-1
Alias CS T626

CST626 is a PROTAC degrader targeting XIAP, cIAP1, and cIAP2.

CST626

CST626

🥰Excellent
Purity: 95.87%
Catalog No. T78947Alias CS T626Cas No. 3033993-13-1
CST626 is a PROTAC degrader targeting XIAP, cIAP1, and cIAP2.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$1,099-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.87%
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Product Introduction

Bioactivity
Description
CST626 is a PROTAC degrader targeting XIAP, cIAP1, and cIAP2.
In vitro
CST626 treated MM.1S cells with DC50,16h values of 2.4 nM (cIAP1), 6.2 nM (cIAP2), and 0.7 nM (XIAP).
The IC50 value of CST626 in MOLM13 and SUDHL6 cells was 2.1 nM and 1.6 nM, respectively.
CST626 (0-10 μM; 96 h) significantly inhibited the activity of cancer cells. [1]
SynonymsCS T626
Chemical Properties
Molecular Weight1103.42
FormulaC61H82N8O9S
Cas No.3033993-13-1
SmilesCC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCOC4=CC(=CC=C4)O[C@H]5C[C@H](N(C5)C(=O)[C@H](C6CCCCC6)NC(=O)[C@H](C)NC)C(=O)N[C@@H]7CCCC8=CC=CC=C78)O
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (72.5 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (2.99 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9063 mL4.5314 mL9.0627 mL45.3137 mL
5 mM0.1813 mL0.9063 mL1.8125 mL9.0627 mL
10 mM0.0906 mL0.4531 mL0.9063 mL4.5314 mL
20 mM0.0453 mL0.2266 mL0.4531 mL2.2657 mL
50 mM0.0181 mL0.0906 mL0.1813 mL0.9063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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