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CST626

Name: CST626
Brand: TargetMol
SKU: T78947
Price: 1099 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: CS T626) Copy Product Info

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Synonyms: CS T626

Catalog No. T78947 Copy Product Info

Purity: 95.87%

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CST626 is a PROTAC degrader targeting XIAP, cIAP1, and cIAP2.

Cas No. 3033993-13-1

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$1,099	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:95.87%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	CST626 is a PROTAC degrader targeting XIAP, cIAP1, and cIAP2.
In vitro	CST626 treated MM.1S cells with DC50,16h values of 2.4 nM (cIAP1), 6.2 nM (cIAP2), and 0.7 nM (XIAP). The IC50 value of CST626 in MOLM13 and SUDHL6 cells was 2.1 nM and 1.6 nM, respectively. CST626 (0-10 μM; 96 h) significantly inhibited the activity of cancer cells. [1]
Synonyms	CS T626

Chemical Properties

Molecular Weight	1103.42
Formula	C₆₁H₈₂N₈O₉S
Cas No.	3033993-13-1
Smiles	CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCOC4=CC(=CC=C4)O[C@H]5C[C@H](N(C5)C(=O)[C@H](C6CCCCC6)NC(=O)[C@H](C)NC)C(=O)N[C@@H]7CCCC8=CC=CC=C78)O

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (72.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (2.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9063 mL	4.5314 mL	9.0627 mL	45.3137 mL
5 mM	0.1813 mL	0.9063 mL	1.8125 mL	9.0627 mL
10 mM	0.0906 mL	0.4531 mL	0.9063 mL	4.5314 mL
20 mM	0.0453 mL	0.2266 mL	0.4531 mL	2.2657 mL
50 mM	0.0181 mL	0.0906 mL	0.1813 mL	0.9063 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.