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E235

Catalog No. T78077 CAS 891894-69-2

E235, an activator of the transcription factor 4 (ATF4), enhances the integrated stress response (ISR) and DNA damage response, thereby reducing cell viability and exhibiting anti-proliferative effects useful in tumor research [1].

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E235, CAS 891894-69-2

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 130.00

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Biological Description

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Description

In vitro

E235 at a concentration of 1 µM induced a time-dependent decrease in the levels of XBP-1s mRNA in HT1080 cells after 2, 4, 8, 16, or 24 hours [1]. Antiproliferative activity of E235 was observed in HT1080, RPMI-8226, B16F10, 4T1, HT1080 shNT, and HT1080 shATF4 cells when treated with concentrations ranging from 0.1 to 10 µM for either 4 or 5 days [1]. Dose-dependent upregulation of p53 expression was seen in AG1522 cells treated with 0, 1, 5, and 10 µM of E235 for 4 hours. Additionally, a 2-hour treatment with 1 µM E235 increased p-Chk2 expression in AG1522 cells [1]. Increases in p-p53 expression were eventuated in both AG1522 and HT1080 cells with E235 dosages of 0, 1, 5, and 10 µM over a 2-hour treatment [1]. Finally, E235 stimulated a dose-dependent increase in expression of γ-H2AX in HT1080 cells with treatments ranging from 0, 0.5, 1, 5, to 10 µM at a 0.5-hour interval [1].

Molecular Weight	484.59
Formula	C28H25FN4OS
CAS No.	891894-69-2

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

E235 891894-69-2 Others inhibitor inhibit

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