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alpha-Ionone

Name: alpha-Ionone
Brand: TargetMol
SKU: TN3385
Rating: 4.5 (1 reviews)

(Synonyms: α-Ionone) Copy Product Info

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Synonyms: α-Ionone

Catalog No. TN3385 Copy Product Info

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alpha-Ionone acts as an agonist for the olfactory receptor OR10A6. It induces apoptosis by activating OR10A6 and increasing the phosphorylation level of the LATS-YAP-TAZ signaling axis in the Hippo pathway, thereby inhibiting tumorigenesis and tumor progression in both in vitro and in vivo experiments.

Cas No. 127-41-3

Pack Size	Price	USA Stock	Global Stock	Quantity
1 g	$29	Inquiry	Inquiry
1 mL	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	alpha-Ionone acts as an agonist for the olfactory receptor OR10A6. It induces apoptosis by activating OR10A6 and increasing the phosphorylation level of the LATS-YAP-TAZ signaling axis in the Hippo pathway, thereby inhibiting tumorigenesis and tumor progression in both in vitro and in vivo experiments.
Targets & IC50	A431 cells:152.4 μM (EC50)
In vitro	Methods: A431 cells were treated with alpha-Ionone (0–1000 μM), and intracellular cAMP levels were detected. Results: alpha-Ionone increased cAMP levels in A431 cells in a dose-dependent manner, with an EC₅₀ of 152.4 μM. Methods: HaCaT cells were treated with alpha-Ionone (100–250 μM). Results: alpha-Ionone inhibited the proliferation of HaCaT cells. Methods: A431 cells were treated with alpha-Ionone (0–200 μM) for 48 hours. Results: alpha-Ionone significantly inhibited the migration of A431 cells in a dose-dependent manner. Methods: A431 cells were treated with alpha-Ionone (100–200 μM). Results: alpha-Ionone increased the phosphorylation levels of LATS, YAP, and TAZ in A431 cells [1].
In vivo	Methods: In the A431 cell xenograft tumor model, alpha-Ionone (200 mg/kg) was intraperitoneally injected into experimental animals once every 3 days for 25 consecutive days. Results: alpha-Ionone activated OR10A6, thereby inhibiting the growth of A431 cell xenograft tumors [1].
Synonyms	α-Ionone

Chemical Properties

Molecular Weight	192.30
Formula	C₁₃H₂₀O
Cas No.	127-41-3
Smiles	C(=C/C(C)=O)\C1C(C)(C)CCC=C1C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160.00 mg/mL (832.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2002 mL	26.0010 mL	52.0021 mL	260.0104 mL
5 mM	1.0400 mL	5.2002 mL	10.4004 mL	52.0021 mL
10 mM	0.5200 mL	2.6001 mL	5.2002 mL	26.0010 mL
20 mM	0.2600 mL	1.3001 mL	2.6001 mL	13.0005 mL
50 mM	0.1040 mL	0.5200 mL	1.0400 mL	5.2002 mL
100 mM	0.0520 mL	0.2600 mL	0.5200 mL	2.6001 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.