Edotecarin

Name: Edotecarin
Brand: TargetMol
SKU: T15200
Rating: 4.5 (1 reviews)

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Catalog No. T15200Cas No. 174402-32-5

Alias PF 804950, J 107088

Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).

Edotecarin

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Catalog No. T15200Alias PF 804950, J 107088Cas No. 174402-32-5

Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).

Pack Size	Price	Availability
25 mg	$2,570	3-6 months
50 mg	$3,380	3-6 months
100 mg	$4,600	3-6 months

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Product Introduction

Bioactivity

Description	Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
Targets&IC50	PKC:160 μM, Topo I:50 nM
In vitro	Edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner, in the presence of human colon cancer cells labeled with 3Hthymidine [1].
In vivo	Edotecarin significantly delays tumor growth, achieving a delay of 10.45 days at a dosage of 3 mg/kg and extending up to 24.83 days at 100 mg/kg. It enhances survival by 83% in mice with D-456MG glioma intracranial tumors and exhibits potent antimetastatic properties [1]. Additionally, combining edotecarin with irinotecan elevates its in vivo antitumor efficacy beyond that observed with either compound individually [2].
Synonyms	PF 804950, J 107088

Chemical Properties

Molecular Weight	608.55
Formula	C₂₉H₂₈N₄O₁₁
Cas No.	174402-32-5
Relative Density.	1.96g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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