Powder: -20°C for 3 years | In solvent: -80°C for 1 year
USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D. USP8-IN-3 inhibited the proliferation of GH3 and H1957 cells with GI50 values of 37.03 μM and 6.01 μM, respectively. USP8-IN-3 is a potential compound for the treatment of cancer and viral infections.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 578.00 | |
100 mg | In stock | $ 833.00 | |
500 mg | In stock | $ 1,690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 127.00 |
Description | USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D. USP8-IN-3 inhibited the proliferation of GH3 and H1957 cells with GI50 values of 37.03 μM and 6.01 μM, respectively. USP8-IN-3 is a potential compound for the treatment of cancer and viral infections. |
Targets&IC50 | USP8D:4.0 μM |
In vitro | SP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively.[1] |
Molecular Weight | 425.43 |
Formula | C18H18F3N5O2S |
CAS No. | 2477651-10-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (58.76 mM)
You can also refer to dose conversion for different animals. More
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USP8-IN-3 2477651-10-6 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB inhibitor inhibit