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MC-GGFG-DX8951

Name: MC-GGFG-DX8951
Brand: TargetMol
SKU: T16024
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16024Cas No. 1600418-29-8

Alias MC-GGFG-Exatecan

MC-GGFG-DX8951 (MC-GGFG-Exatecan) is an antibody-coupled drug (ADC) drug-linker conjugate (DLC) consisting of DX8951, a potent DNA topoisomerase I inhibitor, the linker MC, and the cleavable peptide chain GGFG, and has antitumor potential.

MC-GGFG-DX8951

🥰Excellent

Purity: 99.04%

Catalog No. T16024Alias MC-GGFG-ExatecanCas No. 1600418-29-8

Pack Size	Price	Availability
1 mg	$118	In Stock
5 mg	$293	In Stock
10 mg	$469	In Stock
25 mg	$957	In Stock
50 mg	$1,520	In Stock
100 mg	$2,430	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.04%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MC-GGFG-DX8951 (MC-GGFG-Exatecan) is an antibody-coupled drug (ADC) drug-linker conjugate (DLC) consisting of DX8951, a potent DNA topoisomerase I inhibitor, the linker MC, and the cleavable peptide chain GGFG, and has antitumor potential.
In vitro	MC-GGFG-DX8951 is linked to an antibody through a protease-cleavable MC-GGFG linker for targeted delivery.
In vivo	MC-GGFG-DX8951 has properties such as stability in blood circulation, specific release in tumor tissue, and minimal toxicity to normal tissues [1].
Synonyms	MC-GGFG-Exatecan

Chemical Properties

Molecular Weight	946.98
Formula	C₄₉H₅₁FN₈O₁₁
Cas No.	1600418-29-8
Smiles	N(C(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(=O)C=CC2=O)=O)=O)=O)=O)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8
Relative Density.	1.48 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40.00 mg/mL (42.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0560 mL	5.2799 mL	10.5599 mL	52.7994 mL
5 mM	0.2112 mL	1.0560 mL	2.1120 mL	10.5599 mL
10 mM	0.1056 mL	0.5280 mL	1.0560 mL	5.2799 mL
20 mM	0.0528 mL	0.2640 mL	0.5280 mL	2.6400 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc