Shopping Cart

Remove All
Your shopping cart is currently empty

4A3-SC8

Name: 4A3-SC8
Brand: TargetMol
SKU: T78526
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T78526Cas No. 1857340-78-3

Alias 4A3SC8, 4A3 SC8

4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.

4A3-SC8

😃Good

Purity: 99.87%

Catalog No. T78526Alias 4A3SC8, 4A3 SC8Cas No. 1857340-78-3

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$197	In Stock
10 mg	$323	In Stock
25 mg	$649	In Stock
50 mg	$1,060	8-10 weeks

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.87%

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.
In vitro	4A3-SC8 (100 mg/kg) is a biodegradable dendrimer with low toxicity and high delivery efficiency in mice carrying invasive liver cancer[1].
In vivo	After intravenous injection of 1 mg/kg siRNA, 4A3-SC8 mediated the primary accumulation of siRNA in the liver, with lesser amounts in the spleen and kidneys, and resulted in greater than 95% knockdown of FVII in mice [1]. Following administration of 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), the mice exhibited illness and a significant weight loss of nearly 20% on the first day post injection [1].
Synonyms	4A3SC8, 4A3 SC8

Chemical Properties

Molecular Weight	1467.18
Formula	C₇₅H₁₃₉N₃O₁₆S₄
Cas No.	1857340-78-3
Smiles	O=C(OCCOC(=O)C(C)CSCCCCCCCC)CCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCCN(C)CCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (54.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6816 mL	3.4079 mL	6.8158 mL	34.0790 mL
5 mM	0.1363 mL	0.6816 mL	1.3632 mL	6.8158 mL
10 mM	0.0682 mL	0.3408 mL	0.6816 mL	3.4079 mL
20 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7039 mL
50 mM	0.0136 mL	0.0682 mL	0.1363 mL	0.6816 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc