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4A3-SC8

Name: 4A3-SC8
Brand: TargetMol
SKU: T78526
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78526Cas No. 1857340-78-3

Alias 4A3SC8, 4A3 SC8

4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.

4A3-SC8

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Purity: 99.87%

Catalog No. T78526Alias 4A3SC8, 4A3 SC8Cas No. 1857340-78-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	-	In Stock
5 mg	$197	-	In Stock
10 mg	$323	-	In Stock
25 mg	$649	-	In Stock
50 mg	$1,060	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Liquid

Color:Transparent

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COA LCMS

Product Introduction

Bioactivity

Description	4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.
In vitro	4A3-SC8 (100 mg/kg) is a biodegradable dendrimer with low toxicity and high delivery efficiency in mice carrying invasive liver cancer[1].
In vivo	After intravenous injection of 1 mg/kg siRNA, 4A3-SC8 mediated the primary accumulation of siRNA in the liver, with lesser amounts in the spleen and kidneys, and resulted in greater than 95% knockdown of FVII in mice [1]. Following administration of 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), the mice exhibited illness and a significant weight loss of nearly 20% on the first day post injection [1].
Synonyms	4A3SC8, 4A3 SC8

Chemical Properties

Molecular Weight	1467.18
Formula	C₇₅H₁₃₉N₃O₁₆S₄
Cas No.	1857340-78-3
Smiles	O=C(OCCOC(=O)C(C)CSCCCCCCCC)CCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCCN(C)CCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (54.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6816 mL	3.4079 mL	6.8158 mL	34.0790 mL
5 mM	0.1363 mL	0.6816 mL	1.3632 mL	6.8158 mL
10 mM	0.0682 mL	0.3408 mL	0.6816 mL	3.4079 mL
20 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7039 mL
50 mM	0.0136 mL	0.0682 mL	0.1363 mL	0.6816 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc