Powder: -20°C for 3 years | In solvent: -80°C for 1 year
D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = <500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 28.00 | |
1 mg | 35 days | $ 45.00 | |
5 mg | 35 days | $ 175.00 | |
10 mg | 35 days | $ 294.00 |
Description | D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner. |
Molecular Weight | 361.56 |
Formula | C23H39NO2 |
CAS No. | 143492-38-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 0.1 mg/mL
Ethanol: 20 mg/mL
DMF: 20 mg/mL
Ethanol:PBS (pH 7.2) (1:2): 0.5 mg/mL
You can also refer to dose conversion for different animals. More
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D-erythro-MAPP 143492-38-0 D erythro MAPP DerythroMAPP inhibitor inhibit