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Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $190 | In Stock | |
5 mg | $410 | In Stock | |
10 mg | $615 | In Stock | |
25 mg | $1,045 | In Stock | |
50 mg | $1,570 | In Stock | |
100 mg | $2,355 | In Stock |
Description | Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity. |
In vitro | Trimethylcolchicinic acid exhibits strong antimitotic effects in vitro. When applied to cultured mouse lymphocytes and HeLa cells at a concentration of 1 × 10⁻⁷ M for 24 hours, caused disruption of spindle formation and blockage of mitosis, indicating microtubule inhibition similar to colchicine[1]. |
In vivo | In vivo studies in mice demonstrated that intraperitoneal injection of Trimethylcolchicinic acid (0.5–2 mg/kg) produced pronounced antimitotic effects and disrupted nuclear division in bone marrow cells. After 3 days of treatment, the mitotic index was significantly reduced, indicating potent microtubule interference in vivo[1]. |
Alias | N-Deacetylcolchiceine |
Molecular Weight | 343.37 |
Formula | C19H21NO5 |
Cas No. | 3482-37-9 |
Smiles | O(C)C1=C2C=3C(=CC(=O)C(O)=CC3)[C@@H](N)CCC2=CC(OC)=C1OC |
Relative Density. | no data available |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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