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Trimethylcolchicinic acid

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Catalog No. T204087Cas No. 3482-37-9
Alias N-Deacetylcolchiceine

Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity.

Trimethylcolchicinic acid

Trimethylcolchicinic acid

🥰Excellent
Purity: 100%
Catalog No. T204087Alias N-DeacetylcolchiceineCas No. 3482-37-9
Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity.
Pack SizePriceAvailabilityQuantity
1 mg$190In Stock
5 mg$410In Stock
10 mg$615In Stock
25 mg$1,045In Stock
50 mg$1,570In Stock
100 mg$2,355In Stock
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Purity:100%
ee:100%
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Product Introduction

Bioactivity
Description
Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity.
In vitro
Trimethylcolchicinic acid exhibits strong antimitotic effects in vitro. When applied to cultured mouse lymphocytes and HeLa cells at a concentration of 1 × 10⁻⁷ M for 24 hours, caused disruption of spindle formation and blockage of mitosis, indicating microtubule inhibition similar to colchicine[1].
In vivo
In vivo studies in mice demonstrated that intraperitoneal injection of Trimethylcolchicinic acid (0.5–2 mg/kg) produced pronounced antimitotic effects and disrupted nuclear division in bone marrow cells. After 3 days of treatment, the mitotic index was significantly reduced, indicating potent microtubule interference in vivo[1].
AliasN-Deacetylcolchiceine
Chemical Properties
Molecular Weight343.37
FormulaC19H21NO5
Cas No.3482-37-9
SmilesO(C)C1=C2C=3C(=CC(=O)C(O)=CC3)[C@@H](N)CCC2=CC(OC)=C1OC
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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