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Trimethylcolchicinic acid
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Catalog No. T204087Cas No. 3482-37-9
Alias N-Deacetylcolchiceine
Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity.
Trimethylcolchicinic acid
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Catalog No. T204087Alias N-DeacetylcolchiceineCas No. 3482-37-9
Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $190 | - | In Stock | |
| 5 mg | $410 | - | In Stock | |
| 10 mg | $615 | - | In Stock | |
| 25 mg | $1,045 | - | In Stock | |
| 50 mg | $1,570 | - | In Stock | |
| 100 mg | $2,355 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:>99.99%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity. |
| In vitro | Trimethylcolchicinic acid exhibits strong antimitotic effects in vitro. When applied to cultured mouse lymphocytes and HeLa cells at a concentration of 1 × 10⁻⁷ M for 24 hours, caused disruption of spindle formation and blockage of mitosis, indicating microtubule inhibition similar to colchicine[1]. |
| In vivo | In vivo studies in mice demonstrated that intraperitoneal injection of Trimethylcolchicinic acid (0.5–2 mg/kg) produced pronounced antimitotic effects and disrupted nuclear division in bone marrow cells. After 3 days of treatment, the mitotic index was significantly reduced, indicating potent microtubule interference in vivo[1]. |
| Synonyms | N-Deacetylcolchiceine |
| Molecular Weight | 343.37 |
| Formula | C19H21NO5 |
| Cas No. | 3482-37-9 |
| Smiles | O(C)C1=C2C=3C(=CC(=O)C(O)=CC3)[C@@H](N)CCC2=CC(OC)=C1OC |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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