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Ned 19

Name: Ned 19
Brand: TargetMol
SKU: T12205
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12205Cas No. 874374-25-1

Ned 19, a selective membrane-permeant non-competitive antagonist of NAADP, strongly inhibits tumor growth, vascularization, and lung metastases in mice.

Ned 19

🥰Excellent

Purity: 99.66%

Catalog No. T12205Cas No. 874374-25-1

Ned 19, a selective membrane-permeant non-competitive antagonist of NAADP, strongly inhibits tumor growth, vascularization, and lung metastases in mice.

Pack Size	Price	Availability
1 mg	$58	In Stock
2 mg	$84	In Stock
5 mg	$139	In Stock
10 mg	$213	In Stock
25 mg	$359	In Stock
50 mg	$533	In Stock
100 mg	$759	In Stock
500 mg	$1,530	In Stock
1 mL x 10 mM (in DMSO)	$157	In Stock

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Batch Information

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Purity:99.66%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

Ned 19, a selective membrane-permeant non-competitive antagonist of NAADP, strongly inhibits tumor growth, vascularization, and lung metastases in mice.

Chemical Properties

Molecular Weight	514.59
Formula	C₃₀H₃₁FN₄O₃
Cas No.	874374-25-1
Smiles	C(O)(=O)C1CC2=C(C(N1)C3=CC(CN4CCN(CC4)C5=C(F)C=CC=C5)=C(OC)C=C3)NC=6C2=CC=CC6
Relative Density.	1.316 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (116.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9433 mL	9.7165 mL	19.4329 mL	97.1647 mL
5 mM	0.3887 mL	1.9433 mL	3.8866 mL	19.4329 mL
10 mM	0.1943 mL	0.9716 mL	1.9433 mL	9.7165 mL
20 mM	0.0972 mL	0.4858 mL	0.9716 mL	4.8582 mL
50 mM	0.0389 mL	0.1943 mL	0.3887 mL	1.9433 mL
100 mM	0.0194 mL	0.0972 mL	0.1943 mL	0.9716 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc