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PhiKan 083 hydrochloride

Name: PhiKan 083 hydrochloride
Brand: TargetMol
SKU: T16523
Rating: 4.5 (1 reviews)

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Catalog No. T16523Cas No. 1050480-30-2

PhiKan 083 hydrochloride, a carbazole derivative, binds to the surface cavity and stabilizes Y220C (Kd: 167 μM) with a relative binding affinity (Kd) of 150 μM in Ln229 cells.

PhiKan 083 hydrochloride

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Catalog No. T16523Cas No. 1050480-30-2

PhiKan 083 hydrochloride, a carbazole derivative, binds to the surface cavity and stabilizes Y220C (Kd: 167 μM) with a relative binding affinity (Kd) of 150 μM in Ln229 cells.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$896	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	PhiKan 083 hydrochloride, a carbazole derivative, binds to the surface cavity and stabilizes Y220C (Kd: 167 μM) with a relative binding affinity (Kd) of 150 μM in Ln229 cells.
Targets&IC50	p53-Y220C:（kd）167 μM
In vitro	PhiKan 083 slows down its thermal denaturation rate. PhiKan 083 shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells. PhiKan 083 (100 μM) in combination with NSC 123127 (1 μM) increases the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W). PhiKan 083 (125 μM, 48 hours) decreases the cell viability of engineered variants of Ln229 cells [2][3].

Chemical Properties

Molecular Weight	274.79
Formula	C₁₆H₁₉ClN₂
Cas No.	1050480-30-2
Smiles	Cl.CCn1c2ccccc2c2cc(CNC)ccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 2 mg/mL (7.28 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.6391 mL	18.1957 mL	36.3914 mL	181.9571 mL
5 mM	0.7278 mL	3.6391 mL	7.2783 mL	36.3914 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc