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Jasplakinolide

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Catalog No. T11712Cas No. 102396-24-7
Alias NSC-613009, Jaspamide

Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.

Jasplakinolide

Jasplakinolide

😃Good
Catalog No. T11712Alias NSC-613009, JaspamideCas No. 102396-24-7
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
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100 μg$99835 days35 days
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
In vitro
Jasplakinolide, at a concentration of 1 mM for 60 minutes, prompts the development of apical extensions rich in actin within fixed Toxoplasma gondii tachyzoites. It exhibits an IC50 of 35 nM against PC3 prostate carcinoma cells, underscoring its potent antiproliferative capability. Additionally, when introduced at 10 μM for 2 hours during mitosis, jasplakinolide leads to the formation of binucleated cells. This compound also triggers the production of F-actin-enriched apical extensions in Toxoplasma gondii tachyzoites, demonstrating its broad impact on cellular architecture.[1][2]
SynonymsNSC-613009, Jaspamide
Chemical Properties
Molecular Weight709.67
FormulaC36H45BrN4O6
Cas No.102396-24-7
SmilesC(C=1C=2C(NC1Br)=CC=CC2)[C@@H]3C(=O)N[C@H](CC(=O)O[C@@H](C)C[C@@H](C)\C=C(\C)/C[C@H](C)C(=O)N[C@@H](C)C(=O)N3C)C4=CC=C(O)C=C4
Relative Density.1.227g/cm3
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
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Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

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Keywords

NSC613009NSC 613009MicrotubuleAssociatedMicrotubule AssociatedJasplakinolideFungalArp2/3 complex
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