store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorectal and lung squamous carcinoma cells and dose-dependently downregulates c-Myc cellular levels through the ubiquitin-proteasome system. -proteasome system to dose-dependently downregulate cellular levels of c-Myc.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 722.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorectal and lung squamous carcinoma cells and dose-dependently downregulates c-Myc cellular levels through the ubiquitin-proteasome system. -proteasome system to dose-dependently downregulate cellular levels of c-Myc. |
Targets&IC50 | USP28:0.04 μM |
In vitro | USP28-IN-4 (12.5 μM, 15 μM; 3 days) induces cytotoxicity in human colorectal cancer and lung squamous cell carcinoma cells and significantly enhances the sensitivity of colorectal cancer cells to regorafenib[1]. |
Molecular Weight | 461.36 |
Formula | C22H18Cl2N2O3S |
CAS No. | 2931509-15-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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USP28-IN-4 2931509-15-6 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB inhibitor inhibit