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(S)-DI-87
🥰Excellent
Catalog No. T39550LCas No. 2107280-58-8
Alias (S)-TRE-515, (S)-DI87
(S)-DI-87((S)-TRE-515) is an isomer of DI-87.DI-87 is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding.DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, resulting in a reduction in dNTP production and cell cycle arrest ( especially in S phase). When combined with thymidine, DI-87 significantly inhibits tumor growth.
(S)-DI-87
(S)-DI-87
🥰Excellent
Catalog No. T39550LAlias (S)-TRE-515, (S)-DI87Cas No. 2107280-58-8
(S)-DI-87((S)-TRE-515) is an isomer of DI-87.DI-87 is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding.DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, resulting in a reduction in dNTP production and cell cycle arrest ( especially in S phase). When combined with thymidine, DI-87 significantly inhibits tumor growth.
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Product Introduction
Bioactivity
Chemical Properties
| Description | (S)-DI-87((S)-TRE-515) is an isomer of DI-87.DI-87 is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding.DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, resulting in a reduction in dNTP production and cell cycle arrest ( especially in S phase). When combined with thymidine, DI-87 significantly inhibits tumor growth. |
| Alias | (S)-TRE-515, (S)-DI87 |
| Cas No. | 2107280-58-8 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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