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Tubulin-IN-52
Catalog No. T205978 Copy Product Info
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Tubulin-IN-52 is a potent, selective tubulin polymerization inhibitor with an IC₅₀ of 2.9 μM. Tubulin-IN-52 induces apoptosis in tumor cells by triggering a caspase cascade via the mitochondrial apoptosis pathway. Tubulin-IN-52 significantly inhibits tumor growth without significant toxicity. Tubulin-IN-52 can be used in cancer-related research.
Tubulin-IN-52
Copy Product Info🥰Excellent
Catalog No. T205978
Tubulin-IN-52 is a potent, selective tubulin polymerization inhibitor with an IC₅₀ of 2.9 μM. Tubulin-IN-52 induces apoptosis in tumor cells by triggering a caspase cascade via the mitochondrial apoptosis pathway. Tubulin-IN-52 significantly inhibits tumor growth without significant toxicity. Tubulin-IN-52 can be used in cancer-related research.
Tubulin-IN-52
Cas No. 2099064-75-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:Yellow
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Product Introduction
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| Description | Tubulin-IN-52 is a potent, selective tubulin polymerization inhibitor with an IC₅₀ of 2.9 μM. Tubulin-IN-52 induces apoptosis in tumor cells by triggering a caspase cascade via the mitochondrial apoptosis pathway. Tubulin-IN-52 significantly inhibits tumor growth without significant toxicity. Tubulin-IN-52 can be used in cancer-related research. |
| In vitro | Methods: PC3MLN4 cells were treated with 1 μM Tubulin-IN-52 for 24 or 48 hours. Cell cycle analysis was performed using PI staining and flow cytometry, and the Dean/Jett/Fox model. Immunofluorescence staining with an anti-α-tubulin antibody was used to assess tubulin organization and quantity. Results: Treatment with Tubulin-IN-52 for 24 hours caused an accumulation of cells in the G2/M phase, while treatment for 48 hours disrupted tubulin organization and reduced tubulin levels. [1] |
| In vivo | Methods: To investigate the antitumor effects of Tubulin-IN-52, male BALB/c nude mice were subcutaneously inoculated with PC3MLN4 cells. When tumor volume reached 35 mm³, intraperitoneal injections of Tubulin-IN-52 (30 mg/kg) were initiated, administered every other day, three times a week, for two weeks. Results: Tubulin-IN-52 significantly inhibited tumor growth but did not cause a significant decrease in body weight.[1] |
| Molecular Weight | 380.40 |
| Formula | C20H20N4O4 |
| Cas No. | 2099064-75-0 |
| Smiles | O=C(OC)NC1=NC=2C=CC(=CC2N1)C(=O)C3=CC=C(C=C3)N(C)C4COC4 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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