a-a 1

ST7710AA1 is a PARP-1 inhibitor that acts by showing significant in vitro target inhibition and capability to substantially bypass the multidrug resistance mediated by Pgp.

Aa1 toxin, sourced from Androctonus australis Garzoni venom, is a neurotoxic peptide that specifically blocks potassium channels and has applications in neurological disease research [1].

Dalbavancin (BI-397), a novel second-generation lipoglycopeptide antibiotic, possesses in vitro activity against a variety of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE),Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively

ST7612AA1 is a novel potent and oral HDCA inhibitor that acts as an HIV-1 latency reactivator. ST7612AA1 showed significant antitumor activity at low concentrations in vitro and in vivo. ST7612AA1 has potential anticancer activity and can be used to study malaria.

A2A receptor antagonist 1 (CPI-444 analog) is an inhibitor of the adenosine A2A receptor and A1 receptor with Ki values of 4 nM and 264 nM, respectively.

Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.

FCHFHS-ST7612AA1 is a part of antibody drug conjugates (ADCs) charged with HDAC inhibitor by a linker, shows antitumor activity[1].

MAC-VC-PABC-ST7612AA1 is a part of antibody drug conjugates (ADCs) charged with HDAC inhibitor by a linker, shows antitumor activity[1].

A2A/A1 AR antagonist-1 (compound 1a) is a potent dual antagonist with Ki values of 5.58 nM and 24.2 nM for A2A and A1 AR, respectively, demonstrating potential for ischemic stroke research [1].

VUAA1, an insect odorant co-receptor (Orco) agonist, activates heteromeric and homomeric Orco-containing channels and can disrupt the behaviors of nuisance insects, thus serving as a tool for insect olfactory research [1] [2].

ST8155AA1, a component of antibody-drug conjugates (ADCs), is tethered to an HDAC inhibitor via a linker and exhibits antitumor activity [1].

ST8154AA1, an antibody-drug conjugate (ADC) component coupled with an HDAC inhibitor via a linker, exhibits antitumor activity [1].

ML179 is a potent and selective inverse agonist of liver receptor homolog-1 (LRH1, NR5A2) with IC50 of 320 nM.

AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity.

Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines. The IC50 values ​​are 26.8 nM for MOLM-13 cells and 165.9 nM for MV-4-11 cells. , OCI-AML-3 cells 315.6 nM. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell cycle arrest and apoptosis in a p53-dependent manner.

Trepibutone is an acidic drug with pH-independent release.

NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent.

A1777, a selective 5-lipoxygenase inhibitor, reduces leukocytes proliferation without affecting the eosinophils of mast cells.

AA 193 selectively inhibits the presecretory reabsorption of uric acid.

AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).

DAA-1097 is a novel ligand of peripheral benzodiazepine receptor.

DAA-1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), acting as a potent and selective agonist at the peripheral benzodiazepine receptor.

AAA-10 is an orally active inhibitor of bile salt hydrolase (BSH) in B. intestinalis, targeting B. thetarBSH (IC50: 10 nM) and B. longumrBSH (IC50: 80 nM).

AAA-10 formic is an orally active inhibitor of intestinal bacterial bile salt hydrolase (BSH), with an IC50 of 10 nM against B. thetarBSH and 80 nM against B. longumrBSH.