Aspartylglucosaminidase/AGA Protein, Human, Recombinant (His)

Catalog No. TMPY-03972

AGA (Aspartylglucosaminidase) is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. Diseases associated with AGA include Aspartylglucosaminuria and Lysosomal Storage Disease. An important paralog of this gene is ASRGL1.

Aspartylglucosaminidase/AGA Protein, Human, Recombinant (His)

Catalog No. TMPY-03972

Pack Size	Price	Availability	Quantity
50 μg	$600	7-10 days

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Product Information

Biological Activity	Measured by its ability to hydrolyze the AspAMC. The specific activity is >300 pmol/min/μg.
Description	AGA (Aspartylglucosaminidase) is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. Diseases associated with AGA include Aspartylglucosaminuria and Lysosomal Storage Disease. An important paralog of this gene is ASRGL1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	CAA39029.1
Synonyms	GA,ASRG,aspartylglucosaminidase,AGU
Construction	A DNA sequence encoding the human AGA (CAA39029.1) (Met1-Ile346) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Ser 24
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	36.1 kDa (predicted); 47, 29, 23 and 20 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	AGA (Aspartylglucosaminidase) is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. Diseases associated with AGA include Aspartylglucosaminuria and Lysosomal Storage Disease. An important paralog of this gene is ASRGL1.

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