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Sirtuin modulator 8

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Catalog No. T206550Cas No. 925437-38-3

Sirtuinmodulator 8 is a modulator of silent information regulator proteins (sirtuins) that activates their activity. It significantly reduces the expression of monocyte chemoattractant protein-1 (MCP-1) while enhancing the expression of fibroblast growth factor 21 (FGF21). Sirtuinmodulator 8 regulates the expression of genes related to inflammation and metabolism, showing potential for research into metabolic diseases [such as diabetes and obesity] and inflammatory diseases.

Sirtuin modulator 8

Sirtuin modulator 8

😃Good
Catalog No. T206550Cas No. 925437-38-3
Sirtuinmodulator 8 is a modulator of silent information regulator proteins (sirtuins) that activates their activity. It significantly reduces the expression of monocyte chemoattractant protein-1 (MCP-1) while enhancing the expression of fibroblast growth factor 21 (FGF21). Sirtuinmodulator 8 regulates the expression of genes related to inflammation and metabolism, showing potential for research into metabolic diseases [such as diabetes and obesity] and inflammatory diseases.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
Sirtuinmodulator 8 is a modulator of silent information regulator proteins (sirtuins) that activates their activity. It significantly reduces the expression of monocyte chemoattractant protein-1 (MCP-1) while enhancing the expression of fibroblast growth factor 21 (FGF21). Sirtuinmodulator 8 regulates the expression of genes related to inflammation and metabolism, showing potential for research into metabolic diseases [such as diabetes and obesity] and inflammatory diseases.
In vitro
Sirtuin modulator 8 (Compound 2) (2 μM) significantly reduces MCP-1 expression in a human white blood cell (WBC) model, indicating its potential to inhibit inflammatory responses.
Chemical Properties
Molecular Weight483.588
FormulaC26H25N7OS
Cas No.925437-38-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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