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EG01449
Catalog No. T214357 Copy Product Info
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EG01449 is a quinoline-based neuropilin-1 (NRP1) antagonist with a Kd of 0.6 µM. It competitively inhibits the binding of VEGFA to NRP1 with an IC50 of 362 nM, preventing VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 can cross the blood-brain barrier, allowing for targeted actions within the central nervous system, and is utilized in pain research.
EG01449
Copy Product Info🥰Excellent
Catalog No. T214357
EG01449 is a quinoline-based neuropilin-1 (NRP1) antagonist with a Kd of 0.6 µM. It competitively inhibits the binding of VEGFA to NRP1 with an IC50 of 362 nM, preventing VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 can cross the blood-brain barrier, allowing for targeted actions within the central nervous system, and is utilized in pain research.
EG01449
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | EG01449 is a quinoline-based neuropilin-1 (NRP1) antagonist with a Kd of 0.6 µM. It competitively inhibits the binding of VEGFA to NRP1 with an IC50 of 362 nM, preventing VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 can cross the blood-brain barrier, allowing for targeted actions within the central nervous system, and is utilized in pain research. |
| In vitro | EG01449 (30 μM; pretreated for 15 minutes) reduces phosphorylation of p38 induced by VEGFA in retinal endothelial cells and hCMEC/D3. In isolated rat lumbar DRG neurons, EG01449 (30 μM) decreases the increase in sodium current induced by VEGFA 165, while EG01449 alone does not significantly affect Na+ currents. |
| In vivo | EG01449 (10, 30 μM; subcutaneous injection; single dose) significantly reduces VEGFA-induced aversion to mechanical stimuli and alleviates VEGFA-induced mechanical and cold allodynia in Sprague-Dawley rats. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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