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M464
Catalog No. T214471 Copy Product Info
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M464 is a potent and orally active non-steroidal anti-inflammatory compound functioning as an NLRP3 inflammasome inhibitor. It works by preventing ASC oligomerization and decreasing ROS production, thereby inhibiting pyroptosis and blocking the expression of downstream Caspase-1 and the release of IL-1β. M464 demonstrates protective effects against acute lung and liver injury in mice and can be utilized in research on NLRP3-related inflammatory diseases.
M464
Copy Product Info🥰Excellent
Catalog No. T214471
M464 is a potent and orally active non-steroidal anti-inflammatory compound functioning as an NLRP3 inflammasome inhibitor. It works by preventing ASC oligomerization and decreasing ROS production, thereby inhibiting pyroptosis and blocking the expression of downstream Caspase-1 and the release of IL-1β. M464 demonstrates protective effects against acute lung and liver injury in mice and can be utilized in research on NLRP3-related inflammatory diseases.
M464
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | M464 is a potent and orally active non-steroidal anti-inflammatory compound functioning as an NLRP3 inflammasome inhibitor. It works by preventing ASC oligomerization and decreasing ROS production, thereby inhibiting pyroptosis and blocking the expression of downstream Caspase-1 and the release of IL-1β. M464 demonstrates protective effects against acute lung and liver injury in mice and can be utilized in research on NLRP3-related inflammatory diseases. |
| In vitro | M464, at concentrations of 3-12 μM, inhibits the expression of marker proteins associated with NLRP3 inflammasome activation, including IL-1β and Caspase-1, as well as suppresses the production of intracellular ROS and the formation of ASC oligomers in J774A.1 and THP-1 cells. Additionally, M464 (3-12 μM; 1 hour) prevents macrophage pyroptosis triggered by NLRP3 inflammasome stimuli in J774A.1 and THP-1 cells. |
| In vivo | Administered at doses of M464 (15, 30, 60 mg/kg; orally; 1 hour prior to LPS injection), the compound reduces LPS-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation. In the same dosage and administration manner, M464 also mitigates acute liver injury in mice triggered by LPS and D-GalN, again through the inhibition of NLRP3 inflammasome activation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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