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LO-3-61
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Catalog No. T211321
LO-3-61 is a JQ-1 analog featuring a truncated fumarylamide group, classified as a BRD4 degrader with PROTAC (protein degradation targeting chimera) properties. It promotes the degradation of both long and short BRD4 isoforms via a CUL4DCAF16-dependent pathway. In MDA-MB-231 cells, LO-3-61 exhibits selectivity in degrading BRD3 and BRD4.
LO-3-61
LO-3-61
😃Good
Catalog No. T211321
LO-3-61 is a JQ-1 analog featuring a truncated fumarylamide group, classified as a BRD4 degrader with PROTAC (protein degradation targeting chimera) properties. It promotes the degradation of both long and short BRD4 isoforms via a CUL4DCAF16-dependent pathway. In MDA-MB-231 cells, LO-3-61 exhibits selectivity in degrading BRD3 and BRD4.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | LO-3-61 is a JQ-1 analog featuring a truncated fumarylamide group, classified as a BRD4 degrader with PROTAC (protein degradation targeting chimera) properties. It promotes the degradation of both long and short BRD4 isoforms via a CUL4DCAF16-dependent pathway. In MDA-MB-231 cells, LO-3-61 exhibits selectivity in degrading BRD3 and BRD4. |
| In vitro | LO-3-61 (0.1-1 μM, 24 h) induces proteasome-mediated degradation of BRD4 in HEK293T cells (WT, CUL4 DCAF16 C173S, CUL4 DCAF16 C178S), with this effect being inhibited in DCAF16 knockout cells. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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