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MBED
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Catalog No. T24433Cas No. 123363-40-6
Alias 9-Methyl-7-bromoeudistomin D
MBED represents a highly specialized synthetic small molecule specifically engineered to modulate the calcium homeostasis within striated muscle fibers by acting as a potent allosteric enhancer of the ryanodine receptor type 1 channel while simultaneously exerting inhibitory effects on the sarcoplasmic reticulum calcium ATPase activity, effectively facilitating the measurable elevation of cytosolic calcium concentrations across various preclinical experimental models to evaluate the disruption of intracellular signaling during strictly monitored laboratory observation periods.
MBED
Copy Product Info😃Good
Catalog No. T24433Alias 9-Methyl-7-bromoeudistomin DCas No. 123363-40-6
MBED represents a highly specialized synthetic small molecule specifically engineered to modulate the calcium homeostasis within striated muscle fibers by acting as a potent allosteric enhancer of the ryanodine receptor type 1 channel while simultaneously exerting inhibitory effects on the sarcoplasmic reticulum calcium ATPase activity, effectively facilitating the measurable elevation of cytosolic calcium concentrations across various preclinical experimental models to evaluate the disruption of intracellular signaling during strictly monitored laboratory observation periods.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks | 1-2 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | MBED represents a highly specialized synthetic small molecule specifically engineered to modulate the calcium homeostasis within striated muscle fibers by acting as a potent allosteric enhancer of the ryanodine receptor type 1 channel while simultaneously exerting inhibitory effects on the sarcoplasmic reticulum calcium ATPase activity, effectively facilitating the measurable elevation of cytosolic calcium concentrations across various preclinical experimental models to evaluate the disruption of intracellular signaling during strictly monitored laboratory observation periods. |
| In vitro | In RyR1-expressing cell models and SR vesicles, MBED increased the open probability of RyR1 channels and inhibited SERCA1-mediated calcium sequestration with IC50 values of 10-30 uM [1]. |
| Synonyms | 9-Methyl-7-bromoeudistomin D |
| Molecular Weight | 356.01 |
| Formula | C12H8Br2N2O |
| Cas No. | 123363-40-6 |
| Smiles | BrC1=CC2=C(C(Br)=C1O)C=3C=CN=CC3N2C |
| Relative Density. | 1.31g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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