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NNRT-IN-10
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Catalog No. T210761Cas No. 2459751-62-1
NNRT-IN-10 is a potent, selective, and orally bioavailable non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1. The compound exhibits EC50 values ranging from 1.16 to 18.3 nM against HIV and its variants. NNRT-IN-10 has favorable pharmacokinetic properties and safety profile, making it suitable for research on AIDS caused by HIV-1.
NNRT-IN-10
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Catalog No. T210761Cas No. 2459751-62-1
NNRT-IN-10 is a potent, selective, and orally bioavailable non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1. The compound exhibits EC50 values ranging from 1.16 to 18.3 nM against HIV and its variants. NNRT-IN-10 has favorable pharmacokinetic properties and safety profile, making it suitable for research on AIDS caused by HIV-1.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NNRT-IN-10 is a potent, selective, and orally bioavailable non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1. The compound exhibits EC50 values ranging from 1.16 to 18.3 nM against HIV and its variants. NNRT-IN-10 has favorable pharmacokinetic properties and safety profile, making it suitable for research on AIDS caused by HIV-1. |
| Targets&IC50 | HIV-1 (WT):1.16 nM (EC50) |
| In vitro | NNRT-IN-10 (Compound 5i3) demonstrates improved resistance profiles and negligible cytotoxicity, with EC 50 values of 1.16 nM for HIV-1 (WT), 2.64 nM for P1579, 12.5 nM for P5375, 3.70 nM for P1833, and 18.3 nM for P5735. In MT-4 cells over five days, NNRT-IN-10 effectively inhibits HIV-1 IIIB replication at nanomolar levels (EC 50 = 1.4 nM). It exhibits weak inhibition against cytochrome P450 enzymes: CYP1A2 (IC 50 = 56.6 μM), CYP2C9 (IC 50 = 6.76 μM), CYP2C19 (IC 50 = 8.47 μM), and CYP2D6 (IC 50 = 12.7 μM). Additionally, NNRT-IN-10 demonstrates potassium channel inhibitory activity in CHO-hERG cells (0.3-40 μM, 24 h), with an IC 50 of 1.48 μM. |
| In vivo | NNRT-IN-10 (Compound 5i3) is well-tolerated at a single oral dose of 800 mg/kg, exhibiting no acute toxicity in mice. |
| Molecular Weight | 568.69 |
| Formula | C31H32N6O3S |
| Cas No. | 2459751-62-1 |
| Smiles | O(C=1C2=C(N=C(NC3CCN(CC4=CC=C(S(C)(=O)=O)C=C4)CC3)N1)N=CC=C2)C5=C(C)C=C(/C=C/C#N)C=C5C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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