Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 814.00 | |
500 μg | 5 days | $ 3,250.00 | |
1 mg | 5 days | $ 5,440.00 |
Description | Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. |
Species | Cynomolgus |
Expression System | E. coli |
Tag | N-His |
Accession Number | A0A2K5USI5 |
Synonyms | Protein-arginine deiminase type-4, HL60 PAD, PAD, PDI5, PADI5, PAD4, HL-60, HL-60 PAD |
Construction | Recombinant Cynomolgus PADI4 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Met1-Pro663.[Accession |A0A2K5USI5] |
Protein Purity | > 95% as determined by Tris-Bis PAGE |
Molecular Weight | The protein has a predicted MW of 76.6 kDa same as Tris-Bis PAGE result. |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Supplied as 0.22μm filtered solution in 20mM Tris, 500mM Nacl,10% Glycerol, 0.5mM TCEP, 1mM EDTA (pH 8.0). |
Stability & Storage |
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. |
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Please read the User Guide of Recombinant Proteins for more specific information.
PADI4 Protein, Cynomolgus, Recombinant (His) Protein-arginine deiminase type-4 HL60 PAD PAD PAD 4 PDI 5 HL 60 PDI-5 PAD-4 HL60 PDI5 PADI 5 PADI-5 PADI5 PAD4 HL-60 HL-60 PAD recombinant recombinant-proteins proteins protein