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Tregitope 289

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Catalog No. TP3633

Tregitope 289 is a peptide derived from the Fc region of immunoglobulin G (IgG) and serves as a highly conserved T cell epitope that promotes the expansion of natural regulatory T cells. When co-delivered with type 1 diabetes (T1D) antigens, it can delay the onset of hyperglycemia and reduce the incidence of diabetes in NOD mouse models. Tregitope 289 is applicable for research in T1D and other autoimmune diseases.

Tregitope 289

Tregitope 289

😃Good
Catalog No. TP3633
Tregitope 289 is a peptide derived from the Fc region of immunoglobulin G (IgG) and serves as a highly conserved T cell epitope that promotes the expansion of natural regulatory T cells. When co-delivered with type 1 diabetes (T1D) antigens, it can delay the onset of hyperglycemia and reduce the incidence of diabetes in NOD mouse models. Tregitope 289 is applicable for research in T1D and other autoimmune diseases.
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Product Introduction

Bioactivity
Description
Tregitope 289 is a peptide derived from the Fc region of immunoglobulin G (IgG) and serves as a highly conserved T cell epitope that promotes the expansion of natural regulatory T cells. When co-delivered with type 1 diabetes (T1D) antigens, it can delay the onset of hyperglycemia and reduce the incidence of diabetes in NOD mouse models. Tregitope 289 is applicable for research in T1D and other autoimmune diseases.
Chemical Properties
FormulaC115H173N31O36
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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