AChE-IN-62

Name: AChE-IN-62
Brand: TargetMol
SKU: T209564
Rating: 4.5 (1 reviews)

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Catalog No. T209564

AChE-IN-62 (Compound 1) is a potent, mixed-type selective inhibitor of acetylcholinesterase (AChE) with an IC50 value of 0.421 μM. It effectively penetrates the blood-brain barrier and offers neuroprotective effects. Additionally, AChE-IN-62 inhibits the aggregation of Aβ1-42 with an IC50 of 44.64 μM. This compound also acts as an effective multi-target-directed ligand (MTDL) and is applicable in Alzheimer's disease research.

AChE-IN-62

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Catalog No. T209564

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Product Introduction

Bioactivity

Description	AChE-IN-62 (Compound 1) is a potent, mixed-type selective inhibitor of acetylcholinesterase (AChE) with an IC50 value of 0.421 μM. It effectively penetrates the blood-brain barrier and offers neuroprotective effects. Additionally, AChE-IN-62 inhibits the aggregation of Aβ1-42 with an IC50 of 44.64 μM. This compound also acts as an effective multi-target-directed ligand (MTDL) and is applicable in Alzheimer's disease research.
In vitro	AChE-IN-62 effectively inhibits the aggregation of Aβ 1−42 with an IC50 value of 44.64 μM when used at a concentration of 50 μM for 24-48 hours. Additionally, at concentrations ranging from 5-20 μM over 24 hours, AChE-IN-62 demonstrates neuroprotective properties by mitigating neurotoxicity mediated by H2O2 (200 μM; 24 h) and Okadaic acid (30 nM; 24 h) in SH-SY5Y and Neuro2A cells.
In vivo	AChE-IN-62 (Compound 1) at doses of 10-20 mg/kg, administered intraperitoneally once daily for 7 consecutive days, mitigates scopolamine-induced (3 mg/kg; intraperitoneal; once daily for 7 days) memory impairment and learning deficits in Swiss albino mice by repairing damage to the cerebral cortex and hippocampus, thereby offering neuroprotection against scopolamine-induced injuries.

Chemical Properties

Formula

C₁₉H₂₁N₅O₃S₂

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc