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YE6144

Name: YE6144
Brand: TargetMol
SKU: T62678
Price: 428 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62678Cas No. 3065657-02-2

Alias YE 6144

YE6144 is a prototype IRF5 inhibitor that selectively blocks IRF5 phosphorylation.YE6144 can also inhibit the production of type 1 IFNs (IC50 = 0.09μM).

YE6144

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Catalog No. T62678Alias YE 6144Cas No. 3065657-02-2

YE6144 is a prototype IRF5 inhibitor that selectively blocks IRF5 phosphorylation.YE6144 can also inhibit the production of type 1 IFNs (IC50 = 0.09μM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$428	-	In Stock
5 mg	$1,280	-	In Stock
10 mg	$2,150	-	In Stock
25 mg	$3,900	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Orange

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Product Introduction

Bioactivity

Description	YE6144 is a prototype IRF5 inhibitor that selectively blocks IRF5 phosphorylation.YE6144 can also inhibit the production of type 1 IFNs (IC50 = 0.09μM).
In vitro	Methods: Human HC PBMC and mouse WT splenocytes were treated with YE6144 (1 μM and 3 μM, 30 minutes), and protein expression was detected by Western blotting. Results: YE6144 inhibited the phosphorylation of IRF5 in the above cells. [1]
In vivo	Methods: YE6144 (40 mg/kg, subcutaneous injection, single dose) was used to treat NZB/W F1 mice with systemic lupus erythematosus (SLE) and its effects were observed. Results: YE6144 was able to inhibit the progression of autoantibody production in mice. Post-onset treatment also inhibited splenomegaly and renal insufficiency. [1]
Synonyms	YE 6144

Chemical Properties

Molecular Weight	447.94
Formula	C₂₁H₂₇ClFN₇O
Cas No.	3065657-02-2
Smiles	C(=C/C1=CC=C(N=N1)N2CCOCC2)\C=3C=4C(=CC(F)=C(NC[C@H](CC)N)C4)NN3.Cl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (122.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (22.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2324 mL	11.1622 mL	22.3244 mL	111.6221 mL
5 mM	0.4465 mL	2.2324 mL	4.4649 mL	22.3244 mL
10 mM	0.2232 mL	1.1162 mL	2.2324 mL	11.1622 mL
20 mM	0.1116 mL	0.5581 mL	1.1162 mL	5.5811 mL
50 mM	0.0446 mL	0.2232 mL	0.4465 mL	2.2324 mL
100 mM	0.0223 mL	0.1116 mL	0.2232 mL	1.1162 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

YE6144

YE6144

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