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SCO-267

Name: SCO-267
Brand: TargetMol
SKU: T39140
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39140Cas No. 1656261-09-4

Alias SCO267

SCO-267 is a full agonist of GPR40/FFAR1 with an EC50 of 12 nM, effectively stimulating insulin secretion and GLP-1 release in diabetic rats, improving glucose tolerance, and can be used for the treatment of type 2 diabetes.

SCO-267

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Purity: 99.89%

Catalog No. T39140Alias SCO267Cas No. 1656261-09-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	-	In Stock
5 mg	$359	-	In Stock
10 mg	$587	-	In Stock
25 mg	$1,170	-	In Stock
50 mg	$1,890	-	In Stock
1 mL x 10 mM (in DMSO)	$486	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	SCO-267 is a full agonist of GPR40/FFAR1 with an EC50 of 12 nM, effectively stimulating insulin secretion and GLP-1 release in diabetic rats, improving glucose tolerance, and can be used for the treatment of type 2 diabetes.
In vitro	Method: The activation of G protein-coupled receptor signaling pathways by SCO-267 was evaluated in CHO cells, including Gαq, Gαs, Gα12/13 pathways and β-arrestin recruitment. Its allosteric interaction with fasiglifam and an endogenous ligand was also analyzed.[1] Result: SCO-267 activated the Gαq, Gαs, and Gα12/13 pathways and induced β-arrestin recruitment. It exhibited allosteric modulation with fasiglifam and an endogenous ligand.[1]
In vivo	Method: In the N-STZ rat model, SCO-267 was administered orally at doses of 1 or 10 mg/kg to evaluate its effects on insulin sensitivity and blood glucose levels. Result: SCO-267 improved insulin sensitivity and exerted a sustained glucose-lowering effect. [1]
Synonyms	SCO267

Chemical Properties

Molecular Weight	614.77
Formula	C₃₆H₄₆N₄O₅
Cas No.	1656261-09-4
Smiles	C(N(CC(C)(C)C)C=1N=C(C)C=CC1)(=O)C2=C(C=C(OC)C=C2)N3CCC(COC4=CC([C@@H](CC(O)=O)[C@@H]5CC5)=CC=N4)CC3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (130.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (5.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6266 mL	8.1331 mL	16.2662 mL	81.3312 mL
5 mM	0.3253 mL	1.6266 mL	3.2532 mL	16.2662 mL
10 mM	0.1627 mL	0.8133 mL	1.6266 mL	8.1331 mL
20 mM	0.0813 mL	0.4067 mL	0.8133 mL	4.0666 mL
50 mM	0.0325 mL	0.1627 mL	0.3253 mL	1.6266 mL
100 mM	0.0163 mL	0.0813 mL	0.1627 mL	0.8133 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc