Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • Endogenous Metabolite
    (95)
  • Apoptosis
    (70)
  • COX
    (61)
  • ADC Linker
    (43)
  • Antibacterial
    (33)
  • NF-κB
    (30)
  • SARS-CoV
    (30)
  • Autophagy
    (26)
  • Antibiotic
    (18)
  • Others
    (1534)
Filter
Search Result
Results for "

as 2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    3282
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    22
    TargetMol | Compound_Libraries
  • Peptide Products
    301
    TargetMol | Peptide_Products
  • Inhibitory Antibodies
    23
    TargetMol | Inhibitory_Antibodies
  • Dye Reagents
    154
    TargetMol | Dye_Reagents
  • PROTAC Products
    114
    TargetMol | PROTAC
  • Natural Products
    501
    TargetMol | Natural_Products
  • Reagent Kits
    3
    TargetMol | Reagent_Kits
  • Recombinant Protein
    715
    TargetMol | Recombinant_Protein
  • Isotope Products
    96
    TargetMol | Isotope_Products
  • Antibody Products
    4
    TargetMol | Antibody_Products
  • Disease Modeling
    7
    TargetMol | Disease_Modeling_Products
  • Cell Research
    449
    TargetMol | Inhibitors_Agonists
AS(3n-2)-Inclisiran
T74249
Inclisiran AS(3n-2), an antisense variant of Inclisiran, features a 2 bp spacer followed by 3 random N sites. Inclisiran itself is a double-stranded small interfering RNA (siRNA) molecule designed to suppress PCSK-9 transcription, thereby reducing LDL cholesterol levels [1].
  • Inquiry Price
Size
QTY
TAS 205
T383501584160-52-0
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis when administered at a dose of 30 mg/kg. 1.Aoyagi, H., Kajiwara, D., Tsunekuni, K., et al.Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitisEur. J. Pharmacol.875173030(2020)
  • Inquiry Price
6-8 weeks
Size
QTY
(-)-Epigallocatechin Gallate
Epigallocatechol Gallate, EGCG
T2988989-51-5
(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.
  • Inquiry Price
Size
QTY
Amlexanox
CHX3673, Amoxanox, AA673
T163968302-57-8
Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
NNK
Nicotine-derived nitrosamine ketone
T2053364091-91-4
NNK is a nicotinic nitrosylated derivative. It activates ERK1 2 and PKCα, and activates Bcl2 phosphorylation at Ser70, as well as c-Myc at Thr58 and Ser62.It can be used to construct mouse models of lung cancer, as well as to induce proliferation and survival of human lung cancer cells.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
PD98059
PD 98059
T2623167869-21-8
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2 50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Astragaloside IV
AST-IV, AS-IV
T297384687-43-4
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1 2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
GIP (3-42), human
Gastric Inhibitory Polypeptide (3-42) (human)
T375891802086-25-4
GIP (3-42), human (Gastric Inhibitory Polypeptide (3-42) (human)) is a peptide that acts as a glucose-dependent proinsulinotropic polypeptide (GIP) receptor antagonist and regulates insulin secretion and the metabolic effects of GIP in vivo, which can be used to study type 2 diabetes.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Polyphyllin I
T389550773-41-6
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
NF-κΒ activator 1
T399652387524-59-4
NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide dismutase (SOD) 2 1 mRNA expression.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
L-Lactic acid
L-(+)-Lactic acid, 2-HYDROXYPROPIONIC ACID, (S)-2-Hydroxypropanoic acid
T484579-33-4
L-Lactic acid ((S)-2-Hydroxypropanoic acid) is a natural product produced by the anaerobic glycolysis of pyruvic acid. L-Lactic acid is a sensitive indicator of tissue hypoxia and can be used as a hemodynamic indicator in critically ill patients.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Dehydrocorydaline
Dehydrocorydalin, 13-Methylpalmatine
T5S235830045-16-0
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax Bcl-2, activating caspases as well as cleaving PARP.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
GA-017
T600132351906-74-4
GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1 2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].
  • Inquiry Price
7-10 days
Size
QTY
TargetMol | Inhibitor Hot
2-Deoxy-D-glucose
NSC 15193, D-Arabino-2-deoxyhexose, Ba 2758, 2-DG, 2-deoxyglucose, 2-Deoxy-D-arabino-hexose
T6742154-17-6
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
urotensin i acetate (83930-33-0 free base)
TP1199L
Urotensin I acetate, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively[1][2].
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
1-Methylcytosine
N-Methylcytosine, 4-amino-1-methylpyrimidin-2(1H)-one, 1-methylcytosin
T100191122-47-0In house
1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired with isoguanine.
  • Inquiry Price
6-8 weeks
Size
QTY
COX-2-IN-2
T10032134729-13-8In house
COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.
  • Inquiry Price
6-8 weeks
Size
QTY
BD-AcAc 2
Ketone Ester
T104921208313-97-6In house
BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson's disease.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
CDK9-IN-10
T107423542-63-0In house
CDK9-IN-10 is a potent inhibitor of CDK9 and serves as the ligand for the PROTAC CDK9 degrader-2.
  • Inquiry Price
6-8 weeks
Size
QTY
csn5i-3
T108952375740-98-8In house
CSN5i-3 is a potent, selective, and orally available inhibitor of the proteolytic subunit of the CSN complex, CSN5. It inhibits CSN-catalyzed Cul1 deneddylation with an IC50 value of 5.8 nM. CSN5i-3 has a killing effect on a variety of cancer cells and can be used as an anticancer drug. [2]
  • Inquiry Price
6-8weeks
Size
QTY
GCN2-IN-1
A-92
T113731448693-69-3In house
GCN2-IN-1 (A-92) is an effective GCN2 inhibitor and can be utilized in cancer research as a chemotherapeutic agent.
  • Inquiry Price
6-8 weeks
Size
QTY
Antibacterial compound 2
T11427170104-58-2In house
Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci, enterococci and streptococci, as well as anaerobic bacteria.
  • Inquiry Price
8-10 weeks
Size
QTY
RO5263397
T127451357266-05-7In house
RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies. It has also been found to act as an inhibitor of the enzyme cyclooxygenase-2 (COX-2), which is involved in the synthesis of prostaglandins.
  • Inquiry Price
8-10weeks
Size
QTY
Fmoc-PEA
T17977329223-23-6In house
Fmoc-PEA (Example 1-2) is utilized as a cleavable linker for antibody-drug conjugates (ADC).
  • Inquiry Price
Size
QTY