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Survivin-IN-2
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Catalog No. T211743
Survivin-IN-2 is a survivin inhibitor exhibiting cytotoxic effects on C4-2 and PC-3 cells, with IC50 values of 0.53 μM and 1.06 μM, respectively. It effectively suppresses xenograft tumor growth without significant toxicity and reduces survivin protein levels in tumor tissues, making it useful for prostate cancer research.
Survivin-IN-2
Survivin-IN-2
Copy Product Info😃Good
Catalog No. T211743
Survivin-IN-2 is a survivin inhibitor exhibiting cytotoxic effects on C4-2 and PC-3 cells, with IC50 values of 0.53 μM and 1.06 μM, respectively. It effectively suppresses xenograft tumor growth without significant toxicity and reduces survivin protein levels in tumor tissues, making it useful for prostate cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Survivin-IN-2 is a survivin inhibitor exhibiting cytotoxic effects on C4-2 and PC-3 cells, with IC50 values of 0.53 μM and 1.06 μM, respectively. It effectively suppresses xenograft tumor growth without significant toxicity and reduces survivin protein levels in tumor tissues, making it useful for prostate cancer research. |
| In vitro | Survivin-IN-2 (Compound 7I14) at a concentration of 1 μM for 48 hours reduces survivin expression in C4-2 and PC-3 cells. Additionally, Survivin-IN-2 at concentrations ranging from 450 to 1000 nM exhibits decreased cytotoxic activity in C4-2 cells with survivin overexpression and in Docetaxel-resistant DU145 cells (DU145Doc). |
| In vivo | Survivin-IN-2 (Compound 7I14) administered at 15 mg/kg via intraperitoneal injection twice weekly for four weeks effectively inhibits tumor growth in mice xenografted with PC-3 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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