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Survivin-IN-2
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Catalog No. T211743
Survivin-IN-2 is a survivin inhibitor exhibiting cytotoxic effects on C4-2 and PC-3 cells, with IC50 values of 0.53 μM and 1.06 μM, respectively. It effectively suppresses xenograft tumor growth without significant toxicity and reduces survivin protein levels in tumor tissues, making it useful for prostate cancer research.
Survivin-IN-2
Survivin-IN-2
😃Good
Catalog No. T211743
Survivin-IN-2 is a survivin inhibitor exhibiting cytotoxic effects on C4-2 and PC-3 cells, with IC50 values of 0.53 μM and 1.06 μM, respectively. It effectively suppresses xenograft tumor growth without significant toxicity and reduces survivin protein levels in tumor tissues, making it useful for prostate cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Survivin-IN-2 is a survivin inhibitor exhibiting cytotoxic effects on C4-2 and PC-3 cells, with IC50 values of 0.53 μM and 1.06 μM, respectively. It effectively suppresses xenograft tumor growth without significant toxicity and reduces survivin protein levels in tumor tissues, making it useful for prostate cancer research. |
| In vitro | Survivin-IN-2 (Compound 7I14) at a concentration of 1 μM for 48 hours reduces survivin expression in C4-2 and PC-3 cells. Additionally, Survivin-IN-2 at concentrations ranging from 450 to 1000 nM exhibits decreased cytotoxic activity in C4-2 cells with survivin overexpression and in Docetaxel-resistant DU145 cells (DU145Doc). |
| In vivo | Survivin-IN-2 (Compound 7I14) administered at 15 mg/kg via intraperitoneal injection twice weekly for four weeks effectively inhibits tumor growth in mice xenografted with PC-3 cells. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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