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Lactisole

Name: Lactisole
Brand: TargetMol
SKU: T35795
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35795Cas No. 150436-68-3

Alias na-PMP

Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor

Lactisole

🥰Excellent

Purity: 99.9%

Catalog No. T35795Alias na-PMPCas No. 150436-68-3

Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$33	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor
Targets&IC50	Sweet taste receptor:∼4 mM
In vitro	In MIN6 cells, in a dose-dependent manner, lactisole inhibited insulin secretion induced by sweeteners, acesulfame-K, sucralose and glycyrrhizin. The IC50 was ～4 mmol/l. Lactisole attenuated the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K but did not affect the elevation of intracellular cAMP concentration ([cAMP]c) induced by these sweeteners. Lactisole also inhibited the action of glucose in MIN6 cells. Thus, lactisole significantly reduced elevations of intracellular [NADH] and intracellular [ATP] induced by glucose, and also inhibited glucose-induced insulin secretion[1].
Synonyms	na-PMP

Chemical Properties

Molecular Weight	218.18
Formula	C₁₀H₁₁NaO₄
Cas No.	150436-68-3
Smiles	[Na+].COc1ccc(OC(C)C([O-])=O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 1 mg/mL (4.58 mM), Sonication is recommended.

DMSO: 45 mg/mL (206.25 mM), Sonication is recommended.

DMF: 20 mg/mL (91.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5834 mL	22.9169 mL	45.8337 mL	229.1686 mL

DMF/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.9167 mL	4.5834 mL	9.1667 mL	45.8337 mL
10 mM	0.4583 mL	2.2917 mL	4.5834 mL	22.9169 mL
20 mM	0.2292 mL	1.1458 mL	2.2917 mL	11.4584 mL
50 mM	0.0917 mL	0.4583 mL	0.9167 mL	4.5834 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0458 mL	0.2292 mL	0.4583 mL	2.2917 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc