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5A2-SC8

Name: 5A2-SC8
Brand: TargetMol
SKU: T74450
Price: 239 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74450Cas No. 1857341-90-2

5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.

5A2-SC8

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Catalog No. T74450Cas No. 1857341-90-2

5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$239	In Stock	In Stock
5 mg	$591	In Stock	In Stock
10 mg	$987	In Stock	In Stock
25 mg	$1,980	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$1,630	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥98%

Color:Transparent

Resource Download

COA CNMR HNMR

Product Introduction

Bioactivity

Description	5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.
In vitro	5A2-SC8 is taken up by hepatocytes by binding to the LDL receptor (LDL-R) on the surface of hepatocytes and undergoing receptor-mediated endocytosis with the aid of a crown of surface-adsorbed ApoE protein. [2]
In vivo	A single dose of 75 mg/kg 5A2-SC8 administered intravenously was well tolerated in chronically ill mice with invasive hepatocellular carcinoma and did not adversely affect survival. [1] Intravenous injection of 0.5 mg/kg 5A2-SC8 was effective in crossing the first barrier of hepatic Kupffer cells and was internalized by hepatocytes after 6 hours in the presence of siFVII labeled with Cy5.5 dye. [2]

Chemical Properties

Molecular Weight	1841.71
Formula	C₉₃H₁₇₃N₅O₂₀S₅
Cas No.	1857341-90-2
Smiles	O=C(OCCOC(=O)C(C)CSCCCCCCCC)CCN(CCNCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCNCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC

Storage & Solubility Information

Storage

keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (43.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5430 mL	2.7149 mL	5.4297 mL	27.1487 mL
5 mM	0.1086 mL	0.5430 mL	1.0859 mL	5.4297 mL
10 mM	0.0543 mL	0.2715 mL	0.5430 mL	2.7149 mL
20 mM	0.0271 mL	0.1357 mL	0.2715 mL	1.3574 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc