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Thiohexam

Name: Thiohexam
Brand: TargetMol
SKU: T9037
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9037Cas No. 95-33-0

Thiohexam is a rubber vulcanization accelerator

Thiohexam

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Purity: 97.33%

Catalog No. T9037Cas No. 95-33-0

Thiohexam is a rubber vulcanization accelerator

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
5 g	$64	-	In Stock
10 g	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.33%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Thiohexam AI Summary

Thiohexam exhibits a wide range of bioactivities, particularly as an inhibitor in various biochemical and cellular assays. It is a potent inhibitor of ALDH1A1 with an IC50 of 794.3 nM, G9a histone lysine methyltransferase at 1778.3 nM, ROR gamma transcriptional activity at 8912.5 nM, and the vitamin D receptor (VDR) with a potency of 10000.0 nM. Additionally, it inhibits TDP1 in vitro with an IC50 of 39810.7 nM and in cells in the absence of CPT with an IC50 of 16788.9 nM, among other targets. The compound demonstrates cytotoxic activity against SH-SY5Y, HepG2, and MCF7 cells with IC50 values greater than 120000.0 nM, 55000.0 nM, and 89200.0 nM, respectively, indicating varying degrees of cell viability inhibition. Furthermore, Thiohexam has shown significant antiviral activity by reducing SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 26.21% at 10 µM, and in VERO-6 cells with an inhibition rate of 0.03% at the same concentration. Notably, Thiohexam is a strong inhibitor of the SARS-CoV-2 3CL-Pro protease with an IC50 of 770.0 nM and demonstrates 24.67% inhibition at 20 µM, although it is much less effective against the MERS 3CL-Pro protease, with no observed inhibition at 10 µM and an IC50 greater than 10000.0 nM. Additionally, the compound shows mixed results in HDAC6 enzyme inhibition assays: 80.03% inhibition in an enzymatic assay with a commercial peptide substrate, -3.25% inhibition with a custom peptide substrate, and 23.24% inhibition in a hit confirmation assay using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Thiohexam is a rubber vulcanization accelerator

Chemical Properties

Molecular Weight	264.41
Formula	C₁₃H₁₆N₂S₂
Cas No.	95-33-0
Smiles	C1CCC(CC1)NSc1nc2ccccc2s1
Relative Density.	1.31~1.34g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (85.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7820 mL	18.9100 mL	37.8201 mL	189.1003 mL
5 mM	0.7564 mL	3.7820 mL	7.5640 mL	37.8201 mL
10 mM	0.3782 mL	1.8910 mL	3.7820 mL	18.9100 mL
20 mM	0.1891 mL	0.9455 mL	1.8910 mL	9.4550 mL
50 mM	0.0756 mL	0.3782 mL	0.7564 mL	3.7820 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc