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3β-Methoxy-2,3-dihydrowithaferin A

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Catalog No. TN1269Cas No. 73365-94-3
Alias Quresimin A, 3beta-Methoxy-2,3-dihydrowithaferin A

3β-Methoxy-2,3-dihydrowithaferin As is a natural withanolide isolated from Withania somnifera exhibiting inhibitory activity against ROR-alpha (IC₅₀=11.3 µM).

3β-Methoxy-2,3-dihydrowithaferin A

3β-Methoxy-2,3-dihydrowithaferin A

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Purity: 99.98%
Catalog No. TN1269Alias Quresimin A, 3beta-Methoxy-2,3-dihydrowithaferin ACas No. 73365-94-3
3β-Methoxy-2,3-dihydrowithaferin As is a natural withanolide isolated from Withania somnifera exhibiting inhibitory activity against ROR-alpha (IC₅₀=11.3 µM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$135-In Stock
5 mg$328-In Stock
10 mg$490-In Stock
25 mg$783-In Stock
50 mg$1,090-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.98%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
3β-Methoxy-2,3-dihydrowithaferin As is a natural withanolide isolated from Withania somnifera exhibiting inhibitory activity against ROR-alpha (IC₅₀=11.3 µM).
In vitro
Withaferin-A (Wi-A) exhibits approximately 90% cytotoxicity against normal cells at 1 μM, while 3β-Methoxy-2,3-dihydrowithaferin A (3βmWi-A) remains well tolerated even at 5-10 μM [1].
Wi-A inhibits clonogenic formation at concentrations as low as 0.1 to 0.3 μM, whereas 3βmWi-A shows no significant effect even at 10-fold higher concentrations [1].
Wi-A treatment increases ROS levels in cells, while 3βmWi-A (0.3, 0.6, or 1.5 μM) reduces ROS levels after cell treatment [1].
SynonymsQuresimin A, 3beta-Methoxy-2,3-dihydrowithaferin A
Chemical Properties
Molecular Weight502.65
FormulaC29H42O7
Cas No.73365-94-3
Smiles[H][C@@]12C[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)[C@@]5([H])CC(C)=C(CO)C(=O)O5)[C@@]4(C)CC[C@]3([H])[C@@]3(C)C(=O)C[C@H](OC)[C@H](O)[C@@]13O2 |t:17|
Relative Density.1.26g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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