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CDK2 degrader 8
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Catalog No. T212637Cas No. 3099145-52-2
CDK2 degrader 8 is a novel bifunctional protein degrader (PROTAC) developed based on patent WO 2025/181261, featuring Cyclopropyl and 1,3,4-Oxadiazole scaffolds. This compound facilitates the formation of a ternary complex between CDK2 and an E3 ubiquitin ligase, mediating the selective ubiquitination and subsequent proteasomal degradation of the target protein. In experimental models, it effectively blocks tumor cell cycle progression by depleting CDK2 levels, thereby demonstrating potent anti-proliferative activity.
CDK2 degrader 8
😃Good
Catalog No. T212637Cas No. 3099145-52-2
CDK2 degrader 8 is a novel bifunctional protein degrader (PROTAC) developed based on patent WO 2025/181261, featuring Cyclopropyl and 1,3,4-Oxadiazole scaffolds. This compound facilitates the formation of a ternary complex between CDK2 and an E3 ubiquitin ligase, mediating the selective ubiquitination and subsequent proteasomal degradation of the target protein. In experimental models, it effectively blocks tumor cell cycle progression by depleting CDK2 levels, thereby demonstrating potent anti-proliferative activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $545 | - | In Stock | |
| 5 mg | $1,200 | - | In Stock | |
| 10 mg | $1,800 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | CDK2 degrader 8 is a novel bifunctional protein degrader (PROTAC) developed based on patent WO 2025/181261, featuring Cyclopropyl and 1,3,4-Oxadiazole scaffolds. This compound facilitates the formation of a ternary complex between CDK2 and an E3 ubiquitin ligase, mediating the selective ubiquitination and subsequent proteasomal degradation of the target protein. In experimental models, it effectively blocks tumor cell cycle progression by depleting CDK2 levels, thereby demonstrating potent anti-proliferative activity. |
| In vitro | In cellular degradation assays, CDK2 degrader 8 demonstrated high potency in inducing the depletion of CDK2 protein across various cancer cell lines. It selectively recruits E3 ligases (such as CRBN or VHL) to promote the proteasomal degradation of CDK2 with low nanomolar DC50 values, leading to significant G1 phase arrest and inhibition of DNA synthesis.[1] |
| Molecular Weight | 561.9 |
| Formula | C25H19ClF3N5O5 |
| Cas No. | 3099145-52-2 |
| Smiles | O=C1NC(=O)C(N2C(=O)C3=CC(=CC(Cl)=C3C2)C4(NC5=NN=C(O5)C=6C=CC(OC(F)(F)F)=CC6)CC4)CC1 |
| Relative Density. | no data available |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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