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VEGFR-2-IN-47
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Catalog No. T210040
VEGFR-2-IN-47 (compound 7g) is a potent VEGFR-2 inhibitor with an IC50 of 0.072 μM. It induces G2/M phase cell cycle arrest and promotes apoptosis in MCF-7 cells, enhancing immune modulation by decreasing TNF-α levels and increasing IL-2 levels. VEGFR-2-IN-47 shows potential for research in breast cancer and liver cancer.
VEGFR-2-IN-47
VEGFR-2-IN-47
Copy Product Info😃Good
Catalog No. T210040
VEGFR-2-IN-47 (compound 7g) is a potent VEGFR-2 inhibitor with an IC50 of 0.072 μM. It induces G2/M phase cell cycle arrest and promotes apoptosis in MCF-7 cells, enhancing immune modulation by decreasing TNF-α levels and increasing IL-2 levels. VEGFR-2-IN-47 shows potential for research in breast cancer and liver cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | VEGFR-2-IN-47 (compound 7g) is a potent VEGFR-2 inhibitor with an IC50 of 0.072 μM. It induces G2/M phase cell cycle arrest and promotes apoptosis in MCF-7 cells, enhancing immune modulation by decreasing TNF-α levels and increasing IL-2 levels. VEGFR-2-IN-47 shows potential for research in breast cancer and liver cancer. |
| Targets&IC50 | VEGFR2:0.072 μM |
| In vitro | VEGFR-2-IN-47 (compound 7g) exhibits highly selective anti-proliferative activity against MCF-7 and HepG2 cancer cells, with IC 50 values of 19.35 and 27.89 μM, respectively, and demonstrates low toxicity towards normal WI-38 cells, with an IC 50 value of 51.14 μM, indicating good safety. At a concentration of 19.35 μM over 72 hours, VEGFR-2-IN-47 causes a reduction in the G0/G1 and S phases and an accumulation in the G2/M phase in MCF-7 cells. Additionally, VEGFR-2-IN-47 enhances apoptosis by downregulating Bcl-2 and upregulating Bax levels, while also modulating the immune response by decreasing TNF-α and increasing IL-2 levels in MCF-7 cells. |
| Formula | C23H22N6O4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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