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Lactisole free acid

Name: Lactisole free acid
Brand: TargetMol
SKU: T89427
Rating: 4.5 (1 reviews)

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Catalog No. T89427Cas No. 13794-15-5

Lactisole free acid acts as a typical antagonist of sweet taste receptors, selectively targeting the T1R3 subunit. T1R3 functions as a glucose-sensing receptor. Additionally, Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets.

Lactisole free acid

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Catalog No. T89427Cas No. 13794-15-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

In vitro

Lactisole free acid, at concentrations of 3-10 mM over a 48-hour exposure, suppresses insulin secretion induced by Acesulfame-K, Sucralose, and Glycyrrhizin in mouse pancreatic β-cells MIN6, with an IC 50 value of approximately 4 mM. Additionally, a 5 mM concentration of Lactisole free acid administered for the same duration attenuates the increase in cytoplasmic Ca2+ concentration ([Ca2+]c) triggered by Sucralose and Acesulfame-K, without affecting the rise in intracellular cAMP levels ([cAMP]c).

Chemical Properties

Molecular Weight	196.2
Formula	C₁₀H₁₂O₄
Cas No.	13794-15-5
Smiles	O=C(O)C(OC1=CC=C(OC)C=C1)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc