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Lactisole free acid

Name: Lactisole free acid
Brand: TargetMol
SKU: T89427
Rating: 4.5 (1 reviews)

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Catalog No. T89427Cas No. 13794-15-5

Lactisole free acid acts as a typical antagonist of sweet taste receptors, selectively targeting the T1R3 subunit. T1R3 functions as a glucose-sensing receptor. Additionally, Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets.

Lactisole free acid

😃Good

Catalog No. T89427Cas No. 13794-15-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description

In vitro

Lactisole free acid, at concentrations of 3-10 mM over a 48-hour exposure, suppresses insulin secretion induced by Acesulfame-K, Sucralose, and Glycyrrhizin in mouse pancreatic β-cells MIN6, with an IC 50 value of approximately 4 mM. Additionally, a 5 mM concentration of Lactisole free acid administered for the same duration attenuates the increase in cytoplasmic Ca2+ concentration ([Ca2+]c) triggered by Sucralose and Acesulfame-K, without affecting the rise in intracellular cAMP levels ([cAMP]c).

Chemical Properties

Molecular Weight	196.2
Formula	C₁₀H₁₂O₄
Cas No.	13794-15-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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