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2,5-PYRIDINEDICARBOXYLIC ACID

Name: 2,5-PYRIDINEDICARBOXYLIC ACID
Brand: TargetMol
SKU: T5388
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5388Cas No. 100-26-5

2,5-Pyridinedicarboxylic Acid is used in the preparation of new derivatives as antiviral agents.

2,5-PYRIDINEDICARBOXYLIC ACID

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Purity: 99.12%

Catalog No. T5388Cas No. 100-26-5

2,5-Pyridinedicarboxylic Acid is used in the preparation of new derivatives as antiviral agents.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.12%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

2,5-PYRIDINEDICARBOXYLIC ACID AI Summary

2,5-PYRIDINEDICARBOXYLIC ACID exhibits bioactivity as an inhibitor of prolyl 4-hydroxylase, with IC50 values ranging from 5180.0 nM to 5500.0 nM and a Ki value of 800.0 nM, suggesting potential therapeutic applications related to the regulation of prolyl hydroxylase activity. It demonstrates inhibition of prolyl 4-hydroxylase activity through various assays, including chromatographic determination and indirect assays. Additionally, 2,5-PYRIDINEDICARBOXYLIC ACID shows strong inhibitory effects on metallo beta lactamase enzymes from various bacteria, with varying levels of activity, particularly notable against Aeromonas hydrophila CphA. The compound also exhibits inhibitory effects on 2-oxoglutarate-dependent human JMJD2E, with IC50 values of 1900000.0 nM and 180000.0 nM, and has a Ki value of 420,000 nM for competitive inhibition of Aeromonas hydrophila CphA. It inhibits human recombinant MMPs, iNOS, 5-lipoxygenase, mushroom tyrosinase, and recombinant anthrax lethal factor, with significant efficacy against MMP3 and mushroom tyrosinase. Furthermore, 2,5-PYRIDINEDICARBOXYLIC ACID shows competitive inhibition against ASADH enzymes from Streptococcus pneumoniae and Vibrio cholerae, with respective Ki values of 690000.0 nM and 1200000.0 nM, and also inhibits human AlkB and KDM4E enzymes with IC50 values of 193000.0 nM and 1900000.0 nM, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

2,5-Pyridinedicarboxylic Acid is used in the preparation of new derivatives as antiviral agents.

Chemical Properties

Molecular Weight	167.12
Formula	C₇H₅NO₄
Cas No.	100-26-5
Smiles	OC(=O)C1=CN=C(C=C1)C(O)=O
Relative Density.	1.551g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (71.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9837 mL	29.9186 mL	59.8372 mL	299.1862 mL
5 mM	1.1967 mL	5.9837 mL	11.9674 mL	59.8372 mL
10 mM	0.5984 mL	2.9919 mL	5.9837 mL	29.9186 mL
20 mM	0.2992 mL	1.4959 mL	2.9919 mL	14.9593 mL
50 mM	0.1197 mL	0.5984 mL	1.1967 mL	5.9837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc