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Nafetolol (Synonyms: K-5407, K 5407)

Catalog No. T33581 Copy Product Info
Purity: 98.91%
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Nafetolol (K 5407) exhibits selective efficacy on cardiac (β1)-adrenergic receptors and serves as an orally active beta-blocker, demonstrating a half-life of approximately 2 hours in canine models.

Nafetolol

Copy Product Info
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Catalog No. T33581
Synonyms K-5407, K 5407

Nafetolol (K 5407) exhibits selective efficacy on cardiac (β1)-adrenergic receptors and serves as an orally active beta-blocker, demonstrating a half-life of approximately 2 hours in canine models.

Nafetolol
Cas No. 42050-23-7
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$252In StockIn Stock
5 mg$762In StockIn Stock
10 mg$1,130In StockIn Stock
25 mg$1,690In StockIn Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Purity:98.91%
Appearance:Solid
Color:Purple
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Product Introduction

Bioactivity
Description
Nafetolol (K 5407) exhibits selective efficacy on cardiac (β1)-adrenergic receptors and serves as an orally active beta-blocker, demonstrating a half-life of approximately 2 hours in canine models.
SynonymsK-5407, K 5407
Chemical Properties
Molecular Weight319.44
FormulaC19H29NO3
Cas No.42050-23-7
SmilesO(CC(CNC(C)(C)C)O)C1=C2C(C3CCC2CC3)=C(O)C=C1
Relative Density.1.136g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (140.87 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1305 mL15.6524 mL31.3048 mL156.5239 mL
5 mM0.6261 mL3.1305 mL6.2610 mL31.3048 mL
10 mM0.3130 mL1.5652 mL3.1305 mL15.6524 mL
20 mM0.1565 mL0.7826 mL1.5652 mL7.8262 mL
50 mM0.0626 mL0.3130 mL0.6261 mL3.1305 mL
100 mM0.0313 mL0.1565 mL0.3130 mL1.5652 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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