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TGF-β/Smad-IN-2
Catalog No. T213266 Copy Product Info
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TGF-β/Smad-IN-2 is an orally active TGF-β/Smad inhibitor. It suppresses TGF-β-induced differentiation of fibroblasts into myofibroblasts and collagen deposition, with an IC50 value of 102 μM for reducing collagen in LL29 cells. TGF-β/Smad-IN-2 acts by modulating the SMAD3/SMAD7 signaling pathway and decreases lung index in mice with pulmonary fibrosis. This compound is applicable in pulmonary fibrosis research.
TGF-β/Smad-IN-2
Copy Product Info🥰Excellent
Catalog No. T213266
TGF-β/Smad-IN-2 is an orally active TGF-β/Smad inhibitor. It suppresses TGF-β-induced differentiation of fibroblasts into myofibroblasts and collagen deposition, with an IC50 value of 102 μM for reducing collagen in LL29 cells. TGF-β/Smad-IN-2 acts by modulating the SMAD3/SMAD7 signaling pathway and decreases lung index in mice with pulmonary fibrosis. This compound is applicable in pulmonary fibrosis research.
TGF-β/Smad-IN-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | TGF-β/Smad-IN-2 is an orally active TGF-β/Smad inhibitor. It suppresses TGF-β-induced differentiation of fibroblasts into myofibroblasts and collagen deposition, with an IC50 value of 102 μM for reducing collagen in LL29 cells. TGF-β/Smad-IN-2 acts by modulating the SMAD3/SMAD7 signaling pathway and decreases lung index in mice with pulmonary fibrosis. This compound is applicable in pulmonary fibrosis research. |
| In vitro | TGF-β/Smad-IN-2 (Compound 10b) at concentrations of 50-100 μM over 48 hours significantly reduces the expression of fibrosis markers (FN1, α-SMA, COLLAGEN1α1, COLLAGEN3α1, TIMP1, VIMENTIN) at the mRNA level, and it inhibits the differentiation of fibroblasts into myofibroblasts induced by TGF-β in LL29 and DHLF cells. Additionally, TGF-β/Smad-IN-2 decreases the protein levels of α-SMA, COLLAGEN3α1, and p-COFILIN in DHLF cells while restoring E-CADHERIN expression in response to TGF-β stimulation. |
| In vivo | TGF-β/Smad-IN-2 (Compound 10b) administered at 150-300 mg/kg via gavage once daily for 14 days, enhances weight recovery and survival rates, and reduces the lung index in C57BL/6 mice with Bleomycin (BLMN)-induced pulmonary fibrosis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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