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(R,R)-LRRK2-IN-7

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Catalog No. TYD-02662Cas No. 2307277-92-3

(R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.

(R,R)-LRRK2-IN-7
Other Forms of (R,R)-LRRK2-IN-7:
LRRK2-IN-7T731762307277-93-4
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(R,R)-LRRK2-IN-7

😃Good
Catalog No. TYD-02662Cas No. 2307277-92-3
(R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.
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10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
(R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.
In vitro
LRRK2-IN-7 (compound 25) is both a substrate for Breast Cancer Resistance Protein (BCRP) in mice and humans and an effective human BCRP inhibitor with a BCRP IC50 of 0.12 μM.
In vivo
In a 7-day dose-limiting toxicity study on rats, LRRK2-IN-7 (compound 25) was well tolerated at doses up to 100 mg/kg administered once daily (AUC tot = 330 μM·h). During an acute (2-hour) PK/PD study in rats, LRRK2-IN-7 (compound 25) demonstrated a dose-dependent reduction of LRRK2 pS935 in the rat striatum, with an EC50 of 0.18 nM.
Chemical Properties
Molecular Weight414.50
FormulaC24H26N6O
Cas No.2307277-92-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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