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WKYMVM 2TFA(187986-17-0(free base))
🥰Excellent
Catalog No. T7484L
WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.
WKYMVM 2TFA(187986-17-0(free base))
🥰Excellent
Purity: 99.82%
Catalog No. T7484L
WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $89 | In Stock | In Stock | |
| 5 mg | $342 | In Stock | In Stock | |
| 10 mg | $513 | In Stock | In Stock | |
| 25 mg | $762 | In Stock | In Stock | |
| 50 mg | $1,130 | In Stock | In Stock | |
| 100 mg | $1,530 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.82%
Appearance:solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist. |
| In vitro | Neutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells[1]. |
| In vivo | Using blood samples withdrawn from 28 AL patients and 31 healthy controls, found that, in the absence of exogenous WKYMVM, WKYMVM receptor and bactericidal activity did not differ between patients and controls.Addition of WKYMVM markedly increased the bactericidal activities of these cells in a dose-dependent manner.During induction chemotherapy, there were significant increases in bactericidal activity in the presence and absence of 1nM WKYMVM, with higher bactericidal activities at the time of complete remission than at the time of diagnosis or on day 15.During consolidation chemotherapy, WKYMVM had no effect on bactericidal activities.Patients showed significant increase in the concentrations of TNF alpha, IL-1b, IL-6 and IL-8, but significant decrease in the concentrations of IL-2, IL-4 and IL-12.TNF alpha, IL-1b and IL-6 showed significant negative correlations with bactericidal activities of patient neutrophils at time of diagnosis, and IL-4 showed a significant positive correlation with bactericidal activities,these findings indicate that WKYMVM enhances bactericidal activity in patients with AL[2]. |
| Molecular Weight | 1084.16 |
| Formula | C45H63F6N9O11S2 |
| Smiles | OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 255 mg/mL (235.21 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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