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(123B9)2-Motif is a selective agonist of the EphA2 receptor with a dissociation constant (Kd) of 4.9 μM and does not bind to EphA4. It functions by inducing phosphorylation and oligomerization of the EphA2 receptor, promoting receptor activation and internalization. (123B9)2-Motif is primarily used in research on targeted drug delivery for cancers overexpressing EphA2, such as breast cancer, to reduce circulating tumor cells and inhibit metastasis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
| Description | (123B9)2-Motif is a selective agonist of the EphA2 receptor with a dissociation constant (Kd) of 4.9 μM and does not bind to EphA4. It functions by inducing phosphorylation and oligomerization of the EphA2 receptor, promoting receptor activation and internalization. (123B9)2-Motif is primarily used in research on targeted drug delivery for cancers overexpressing EphA2, such as breast cancer, to reduce circulating tumor cells and inhibit metastasis. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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