COE-PNH2

Name: COE-PNH2
Brand: TargetMol
SKU: T209445
Rating: 4.5 (1 reviews)

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Catalog No. T209445

COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with an MIC90 of 26 μM. It disrupts bacterial cell wall and membrane integrity, possesses intracellular permeability, and lacks mitochondrial toxicity.

COE-PNH2

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Catalog No. T209445

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Product Introduction

Bioactivity

Description	COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with an MIC90 of 26 μM. It disrupts bacterial cell wall and membrane integrity, possesses intracellular permeability, and lacks mitochondrial toxicity.
In vitro	COE-PNH2 (0-128 μg/mL) demonstrates stable antibacterial activity against intracellular, replicative, and nutrient-deprived Mycobacterium abscessus (Mab) strains with exceptionally high antibiotic tolerance. It exhibits a low propensity for resistance development, maintaining consistent minimum inhibitory concentration (MIC) values over 14 consecutive Mab passages. At concentrations ranging from 0-64 μg/mL, COE-PNH2 induces ATP depletion, intracellular lipid inclusions (ILIs) accumulation, and bacterial elongation in Mab.
In vivo	COE-PNH2 (2.5-5 mg/kg, administered intratracheally every two days for a total of 12 days) demonstrated good tolerability and efficacy in C3HeB/FeJ mice with acute lung infections.

Chemical Properties

Formula

C₅₄H₉₈Cl₈N₈O₄

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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