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NIR-H2O2

Name: NIR-H2O2
Brand: TargetMol
SKU: T19038
Rating: 4.5 (1 reviews)

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Catalog No. T19038

NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor that exhibits a significant turn-on NIR fluorescence signal in response to H2O2 upon excitation in the NIR region.

NIR-H2O2

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Catalog No. T19038

NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor that exhibits a significant turn-on NIR fluorescence signal in response to H2O2 upon excitation in the NIR region.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,700	8-10 weeks	8-10 weeks
50 mg	$2,340	8-10 weeks	8-10 weeks
100 mg	$2,860	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor that exhibits a significant turn-on NIR fluorescence signal in response to H2O2 upon excitation in the NIR region.
In vitro	NIR-H2O2 is highly selective to H2O2 over other typical ROS and bio-relevant species. HeLa cells incubated with NIR-H2O2 (5 μM, 30 min, 37 °C) exhibit minimal fluorescence, but show strong fluorescence upon H2O2 treatment. Similarly, RAW264.7 macrophages loaded with NIR-H2O2 (1 μM) display almost no fluorescence, but when co-incubated with PMA (3.0 μg/mL), show significant red emission. NIR-H2O2 effectively enables fluorescent imaging of endogenous H2O2 in living RAW264.7 macrophages.
In vivo	In an acute inflammation model induced by lipopolysaccharide (LPS), in vivo hydrogen peroxide (H2O2) production was generated by activated macrophages and neutrophils. Mice treated with both LPS and near-infrared-responsive H2O2 (NIR-H2O2) displayed significantly higher fluorescence readouts than those untreated or treated solely with NIR-H2O2. Specifically, fluorescence intensity in mice administrated with LPS and NIR-H2O2 was approximately 10- and 20-fold greater compared to mice treated with saline and the sensor, and mice treated with saline alone, respectively.

Chemical Properties

Molecular Weight	565.89
Formula	C₃₄H₃₃BClNO₄
Smiles	ClC1=CC2=C(OC3=C(CCCC3=C2)/C=C/C4=[N+](C5=C(C4(C)C)C=CC=C5)CC)C=C1OCC6=CC=C(C=C6)B([O-])O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NIR-H-2O2NIR-H2O2NIRH2O2NIR H2O2