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Pam2CSK4 TFA

Catalog No. TP2282L

Synonyms: PUL-042 TFA, ODN-M362 TFA, Pam2CSK4 trifluoroacetate-salt, Pam2CSK4 TFA(868247-72-7 Free base）

Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pam2CSK4 TFA, CAS N/A

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	PUL-042 TFA, ODN-M362 TFA, Pam2CSK4 trifluoroacetate-salt, Pam2CSK4 TFA(868247-72-7 Free base）
Molecular Weight	1385.84
Formula	C67H127F3N10O14S

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kaur A, et al. An efficient and scalable synthesis of potent TLR2 agonistic PAM2CSK4. RSC Adv. 2018 Mar 5;8(18):9587-9596. 2. Kulsantiwong P, et al. Pam2CSK4 and Pam3CSK4 induce iNOS expression via TBK1 and MyD88 molecules in mouse macrophage cell line RAW264.7. Inflamm Res. 2017 Oct;66(10):843-853. 3. Parra-Izquierdo I, et al. The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton's Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions. Front Immunol. 2021 Aug 30;12:729951.

Related Products

Related compounds with same targets

Semapimod tetrahydrochloride Pam3CSK4 TFA (112208-00-1 free base) Hydroxychloroquine Schaftoside TLR7/8-IN-1 SM360320 MD2-TLR4-IN-1 VB 201

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pam2CSK4 TFA Immunology/Inflammation Microbiology/Virology TLR Antifungal PUL-042 TFA ODN-M362 TFA Pam2CSK4 trifluoroacetate-salt Pam2CSK4 TFA(868247-72-7 Free base） inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.