Loaded Mouse APRIL-Fc on AHC Biosensor, can bind Human BCMA-mFc with an affinity constant of <10^-3 nM as determined in BLI assay.
Loaded Human BAFF-Fc on AHC Biosensor, can bind Human BCMA-mFc with an affinity constant of 0.15 nM as determined in BLI assay.
Loaded Human APRIL-His on HIS1K Biosensor, can bind Human BCMA-mFc with an affinity constant of 0.36 nM as determined in BLI assay.

BCMA/TNFRSF17 Protein, Human, Recombinant (mFc) V2 is expressed in HEK293 Cells. The accession number is Q02223 .

Human

HEK293 Cells

tumor necrosis factor receptor superfamily member 17,TNFRSF13A,CD269,BCMA,BCM

Met1-Ala54

> 95% as determined by SDS-PAGE

Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid (aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation.